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Tumor Cell-Endothelial Cell Interactions During Blood Borne Metastasis: Role of Specific Adhesion, Motility, and Growth Molecules

  • Chapter
Cell Adhesion Molecules

Part of the book series: Pezcoller Foundation Symposia ((PFSO,volume 4))

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Abstract

The metastatic spread of blood borne tumor cells to near and distant sites does not occur randomly. Certain tumors tend to metastasize to particular organ sites, and this process appears to be due to differnces in tumor cell and host organ molecular properties (Nicolson, 1988a; Nicolson, 1991; Zetter, 1990). Once in the blood, tumor types cells can circulate to virtually every organ, yet metastases of many common tumor types form only at certain sites (Sugerbaker, 1983). This brief review will consider some of the properties of tumor cells and some of the properties of host organ cells and stroma in the organ preference of metastasis. For addidtional information, the reader is refered to more extensive reviews (Nicolson, 1988a; Nicolson, 1989; Nicolson, 1991; Liotta et al., 1991b).

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Abbreviations

HSE :

Hepatic Sinusoidal Endothelial Cell;

HX :

High;

LDGF-1-γ:

Lung-derived Growth Factor-1;

LX :

Low;

P :

Parental Cell Line;

Tf :

Transferrin Family of Growth Factors

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Authors and Affiliations

  1. Department of Tumor Biology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA

    Garth L. Nicolson, Timothy J. Yeatman, Robert J. Tressler, Timothy V. Updyke, Jun-ichi Hamada & Phillip G. Cavanaugh

Authors
  1. Garth L. Nicolson
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  2. Timothy J. Yeatman
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  3. Robert J. Tressler
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  4. Timothy V. Updyke
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  5. Jun-ichi Hamada
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  6. Phillip G. Cavanaugh
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Editor information

Editors and Affiliations

  1. Dana-Farber Cancer Institute, Boston, Massachusetts, USA

    Martin E. Hemler

  2. Roswell Park Cancer Institute, Buffalo, New York, USA

    Enrico Mihich

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© 1993 Plenum Press, New York

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Nicolson, G.L., Yeatman, T.J., Tressler, R.J., Updyke, T.V., Hamada, Ji., Cavanaugh, P.G. (1993). Tumor Cell-Endothelial Cell Interactions During Blood Borne Metastasis: Role of Specific Adhesion, Motility, and Growth Molecules. In: Hemler, M.E., Mihich, E. (eds) Cell Adhesion Molecules. Pezcoller Foundation Symposia, vol 4. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2830-2_15

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  • DOI: https://doi.org/10.1007/978-1-4615-2830-2_15

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-306-44496-8

  • Online ISBN: 978-1-4615-2830-2

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