Abstract
Parasites of the Leishmania genus are the causative agents of the complex disease called leishmaniasis. Clinical manifestations in this disease range from cutaneous lesions, disseminated cutaneous lesions, mucocutaneous lesions, and visceral disease. Even though immune responses are elicited in response to infection, infection with several Leishmania species is not self-limited. The mechanism(s) by which parasites avoid the lethal effects of the immune response is the subject of intense research. This research includes studies on the identity and targets of the parasite mediators that are deployed to limit effectors of the immune response. This review will profile some of the parasite mediators for which there has been recent progress and the processes that they target.
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Acknowledgment
Studies by P.E.K. were supported by funds from the UF foundation.
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Kima, P.E. (2014). Update on Leishmania Mediators That Promote Immune Evasion. In: Satoskar, A., Durvasula, R. (eds) Pathogenesis of Leishmaniasis. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-9108-8_2
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DOI: https://doi.org/10.1007/978-1-4614-9108-8_2
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