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Clinical Application of NIRS

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Application of Near Infrared Spectroscopy in Biomedicine

Part of the book series: Handbook of Modern Biophysics ((HBBT,volume 4))

Abstract

Near-infrared spectroscopy (NIRS) has several significant advantages over existing radiological techniques in clinical application. Humans do face any accumulation of deleterious x-rays. Unlike ultrasound methods, NIRS does not lead to excess heat, can differentiate between human tissues with varying optical absorption or scatter, can provide functional information, and can measure oxygenation in human tissues without the use of radioisotopes or other contrast agents. However, NIRS has some disadvantages. Quantifying changes with NIRS requires the use of magnetic resonance (MR) or computed tomography (CT) data. Converting measured optical density to Hb/Mb saturation requires the use of complex formulas. Due to their complexity, the formulas will yield inaccurate measurements arising from even small signal interferences.

As Erratum to this chapter is available at http://dx.doi.org/10.1007/978-1-4614-6252-1_10

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Authors and Affiliations

  1. Laboratory for Applied Physiology, University of Tokushima, Tokushima, 770-8502, Japan

    Miura Hajime Ph.D.

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  1. Miura Hajime Ph.D.
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Correspondence to Miura Hajime Ph.D. .

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Editors and Affiliations

  1. BIOCHEMISTRY & MOLECULAR MEDICINE, University of California Davis BIOCHEMISTRY & MOLECULAR MEDICINE, Davis, California, USA

    Thomas Jue

  2. Kanazawa University, Kanazawa, Japan

    Kazumi Masuda

Appendices

Problem

  1. 4.1

    How does NIRS help us better understand the relationship between vasculature and tissue function?

Further Reading

Boushel R, Langberg H, Olesen J, Gonzales-Alonzo J, Bülow J, Kjaer M (2001) Monitoring tissue oxygen availability with near infrared spectroscopy (NIRS) in health and disease. Scand J Med Sci Sports 11(4):213–222

Hebden JC, Delpy DT (1997) Diagnostic imaging with light. Br J Radiol 70:S206–S214

Kondepati VR, Heise HM, Backhaus J (2008) Recent applications of near-infrared spectroscopy in cancer diagnosis and therapy. Anal Bioanal Chem 390(1):125–139

Murkin JM, Arango M (2009) Near-infrared spectroscopy as an index of brain and tissue oxygenation. Br J Anaesth 103(Suppl 1):i3–i13

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Hajime, M. (2013). Clinical Application of NIRS. In: Jue, T., Masuda, K. (eds) Application of Near Infrared Spectroscopy in Biomedicine. Handbook of Modern Biophysics, vol 4. Springer, Boston, MA. https://doi.org/10.1007/978-1-4614-6252-1_4

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