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Obesity and Gastrointestinal Cancers: Epidemiology

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Energy Balance and Gastrointestinal Cancer

Part of the book series: Energy Balance and Cancer ((EBAC,volume 4))

Abstract

There is strong and consistent evidence for associations between obesity and multiple gastrointestinal (GI) cancers. The most consistent and compelling evidence exists for the association between obesity and colon cancer; however, there is emerging evidence for associations between obesity and esophageal adenocarcinoma and, pancreatic and liver cancers. The number of studies evaluating obesity and gastric and gallbladder cancers is limited and results, thus far, have been inconsistent. In this chapter, the epidemiological evidence linking obesity to the development and survival of GI cancers is reviewed. Because obesity plays an integral role in manifestation of the Metabolic Syndrome (MetSyn), epidemiological evidence for associations between MetSyn and GI cancers is also summarized. Other environmental and genetic risk factors for GI cancers and the putative ­mechanisms linking obesity, MetSyn, and GI cancers are discussed in subsequent chapters of this book.

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Acknowledgments

This work was supported, in part, from the National Institutes of Health (NIH) National Cancer Institute (NCI) K07CA129162 awarded to NLN.

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  1. Department of Epidemiology and Biostatistics, Case Western Reserve University, 2103 Cornell Road, Cleveland, OH, 44106-7281, USA

    Nora L. Nock Ph.D.

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  1. Nora L. Nock Ph.D.
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Correspondence to Nora L. Nock Ph.D. .

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  1. , Molecular Biology and Microbiology, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, 44106, Ohio, USA

    Sanford D. Markowitz

  2. School of Medicine, Center for Science, Health & Society, Case Western Reserve University, Euclid Ave. 10900, Cleveland, 44106, Ohio, USA

    Nathan A. Berger

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Nock, N.L. (2012). Obesity and Gastrointestinal Cancers: Epidemiology. In: Markowitz, S., Berger, N. (eds) Energy Balance and Gastrointestinal Cancer. Energy Balance and Cancer, vol 4. Springer, Boston, MA. https://doi.org/10.1007/978-1-4614-2367-6_1

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