Abstract
In discussing the usefulness of isolated tissues in the drug discovery process, as with any model utilized in the characterization of a potential new drug, the question of relevance must be ascertained. The biologist usually interprets the effects of a drug on isolated tissues or organs as an action at the receptor level. However, the question does not have to be targeted toward a particular cellular or mechanistic parameter; it can also be more global in nature, e.g., clinical significance in comparison to known active agents. Usually, the more that is known about a chemical entity or clinical disorder, the more relevant are the in vitro tissue screens (see Williams and Malick, this volume).
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Goodman, F.R. (1987). Use of Intact Tissue Preparations in the Drug Discovery Process. In: Williams, M., Malick, J.B. (eds) Drug Discovery and Development. Humana Press. https://doi.org/10.1007/978-1-4612-4828-6_4
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