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Historeceptomics: Integrating a Drug’s Multiple Targets (Polypharmacology) with Their Expression Pattern in Human Tissues

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Multi-Target Drug Design Using Chem-Bioinformatic Approaches

Part of the book series: Methods in Pharmacology and Toxicology ((MIPT))

Abstract

Historeceptomics is a new, integrative informatics approach to describing the mechanism of action of drugs in a holistic, in vivo context. The approach is based on leveraging emerging big data sources in genomics and chemistry to incorporate tissue specificity into mechanism of action descriptions. New insights into drug mechanism of action, drug repurposing, and prediction of adverse effects may be possible, including the design and development of multi-target drugs or drug combinations. The critical elements still under development include: (1) defining the tissue ensemble associated with specific human diseases, (2) appreciating the pattern or partitioning of the expression of drug targets (receptors) across and outside of these ensembles, and (3) informatics methods to integrate direct drug-receptor data with receptor expression data in tissues. Maturation of this field may enable the complementary field of tissue-targeted drug delivery, enabling novel concepts in drug design and development for unmet medical needs.

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Disclosure

The author is a co-founder of GeneCentrix, Inc., a company developing historeceptomics software.

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Authors and Affiliations

  1. New York University School of Medicine, NYU Langone Health, New York, NY, USA

    Timothy Cardozo

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  1. Timothy Cardozo
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Correspondence to Timothy Cardozo .

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Editors and Affiliations

  1. Department of Pharmaceutical Technology, Jadavpur University, Kolkata, West Bengal, India

    Kunal Roy

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Cardozo, T. (2018). Historeceptomics: Integrating a Drug’s Multiple Targets (Polypharmacology) with Their Expression Pattern in Human Tissues. In: Roy, K. (eds) Multi-Target Drug Design Using Chem-Bioinformatic Approaches. Methods in Pharmacology and Toxicology. Humana Press, New York, NY. https://doi.org/10.1007/7653_2018_15

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  • DOI: https://doi.org/10.1007/7653_2018_15

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-8732-0

  • Online ISBN: 978-1-4939-8733-7

  • eBook Packages: Springer Protocols

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