Abstract
In the United States alone, 25 to 35 million cases of group A streptococcal infections are reported annually, which primarily afflict school-age children. This high incidence of streptococcal disease, with its potential sequelae of rheumatic fever and acute glomerulonephritis, provides the motivation for efforts to develop an effective and safe vaccine to prevent streptococcal-related diseases. Since the observation by Lancefield that antibodies to the M protein have the capacity to opsonize streptococci in preparation for phagocytic clearance (Lancefield, 1928), the M protein has been a prime candidate for a vaccine to prevent group A streptococcal infections (Bessen and Fischetti, 1990c). However, the ability of the organism to change the antigenic appearance of the M molecule (85 M protein types have now been identified) has hindered the development of this protein for use as a vaccine to protect against all existing group A streptococcal serotypes.
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Fischetti, V.A., Bessen, D.E., Schneewind, O., Hruby, D.E. (1992). Protection against Streptococcal Mucosal Colonization. In: Hook, M., Switalski, L. (eds) Microbial Adhesion and Invasion. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-2924-7_12
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DOI: https://doi.org/10.1007/978-1-4612-2924-7_12
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