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Role of Calcium in Stimulus-Secretion Coupling in Exocrine Glands

  • Chapter
Ion Channels and Ion Pumps

Part of the book series: Endocrinology and Metabolism ((EAM,volume 6))

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Abstract

Calcium plays a key role not only in the control of exocrine secretion but also in an extraordinarily diverse group of cellular activities including endocrine secretion, neural transmission, cellular differentiation and growth, intermediary metabolism, protein synthesis, and muscle contraction.1 The overall mechanisms by which intracellular calcium concentrations are regulated in non-excitable cells include the release of calcium from intracellular storage sites and the influx of calcium into the cell from the extracellular environment. In general, elevation of intracellular calcium is thought to result in initial activation of calcium and phospholipid-dependent protein kinases. Through cell specific phosphorylation mechanisms these kinases, in conjunction with opposing phosphatases, may modulate the activities of membrane-bound ion channels, agonist receptors and receptor-associated regulatory enzymes, and many other enzymes present in different cellular compartments.

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  1. Catherine S. Chew
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Editors and Affiliations

  1. 48323, 2104 Rhine Road, West Bloomfield, MI, USA

    Piero P. Foà M.D., Sc.D. (Professor Emeritus) (Professor Emeritus)

  2. Department of Physiology, Wayne State University, 48202, Detroit, MI, USA

    Piero P. Foà M.D., Sc.D. (Professor Emeritus) (Professor Emeritus)

  3. Section of Endocrinology,Department of Internal Medicine,School of Medicine, Wayne State University, 48202, Detroit, MI, USA

    Mary F. Walsh Ph.D. (Assistant Professor) (Assistant Professor)

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Chew, C.S. (1994). Role of Calcium in Stimulus-Secretion Coupling in Exocrine Glands. In: Foà, P.P., Walsh, M.F. (eds) Ion Channels and Ion Pumps. Endocrinology and Metabolism, vol 6. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-2596-6_3

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