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Fatty Acid Biosynthesis and Biologically Significant Acyl Transfer Reactions in Pseudomonads

  • Chapter
Pseudomonas

Abstract

Fatty acid synthesis (FAS) is essential for cellular function by providing precursors for synthesis of numerous cellular constituents, including phospholipids16, lipopolysaccharides84, rhamnolipids9, 72, polyhydroxyalkanoic acids2, 61, oligosaccharides23, 27 and proteins48. More recently, acyl-acyl carrier proteins (acyl-ACPs) derived from the fatty acid biosynthetic (Fab) pathway were shown to be the acyl donors for synthesis of acylated homoserine lactones (AHLs) that are required for cell-to-cell communication and the many processes depending on it41, 43, 67, 76, 100. In addition, fatty acids play numerous other diverse roles in the physiology of pseudomonads. Adaptive alterations of membrane fatty acids and phospholipids play a role in the solvent tolerance of Pseudomonas putida and probably other pseudomonads37, 86. Such adaptive fatty acid alterations also occur in response to changes in growth conditions, with temperature and growth phase being the most influential parameters in Pseudomonas aeruginosa 11. Fatty acid composition of phospholipids also can influence some behavioral traits, such as P. aeruginosa twitching motility up phospholipid gradients53. The unique fatty acid patterns of individual Pseudomonas strains determined by gas chromatographic analysis can be utilized to identify individual bacterial species19, 68, 69. This technology forms the basis of the commercially available Sherlock® microbial identification system (MIDI, Inc., Newark, Delaware, USA).

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  1. Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, 80523-1682, USA

    Herbert P. Schweizer

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  1. CSIC, Granada, Spain

    Juan-Luis Ramos

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Schweizer, H.P. (2004). Fatty Acid Biosynthesis and Biologically Significant Acyl Transfer Reactions in Pseudomonads. In: Ramos, JL. (eds) Pseudomonas. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-9088-4_3

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  • DOI: https://doi.org/10.1007/978-1-4419-9088-4_3

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