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Antioxidants and Sperm DNA Damage

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Sperm Chromatin

Abstract

Infertile men have higher levels of sperm DNA damage than do fertile men, and this damage may reduce male fertility potential and may impact on reproductive capacity. This is particularly important in the context of assisted reproductive technologies, as there is a mounting concern regarding the safety of utilizing DNA-damaged spermatozoa in this setting. A better understanding of the etiology of sperm DNA damage may help identify strategies to reduce sperm DNA damage. In this chapter, we ­discuss the rationale for antioxidant therapy, examine the relationship between oxidative stress and sperm DNA damage, and evaluate the studies on dietary and in vitro antioxidants on sperm DNA damage. The review focuses primarily on clinical (human) studies with some examples taken from experimental (animal) data.

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Authors and Affiliations

  1. Department of Surgery, Division of Urology, McGill University, St. Mary’s Hospital Center, Montreal, QC, Canada

    Armand Zini MD

  2. Division of Urology, Department of Surgery, Royal Victoria Hospital, McGill University, Montreal, QC, Canada

    Maria San Gabriel BS

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  1. St. Mary's Hospital, Div. Urology, McGill University, Lacombe Avenue 3830, Montreal, H3T 1M5, Québec, Canada

    Armand Zini

  2. Lerner College of Medicine, Center for Reproductive Medicine, Cleveland Clinic, Euclid Avenue 9500, Cleveland, 44195, Ohio, USA

    Ashok Agarwal

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Zini, A., Gabriel, M.S. (2011). Antioxidants and Sperm DNA Damage. In: Zini, A., Agarwal, A. (eds) Sperm Chromatin. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-6857-9_30

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