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Calcium Channels

  • Chapter
Biological Membrane Ion Channels

Part of the book series: Biological And Medical Physics Biomedical Engineering ((BIOMEDICAL))

Abstract

Ion channels underlie the electrical activity of cells. Calcium channels have a unique functional role, because not only do they participate in this activity, they form the means bywhich electrical signals are converted to responses within the cell. Calcium concentrations in the cytoplasm of cells are maintained at a low level, and calcium channels activate quickly such that the opening of ion channels can rapidly change the cytoplasmic environment. Once inside the cell, calcium acts as a “second messenger” prompting responses by binding to a variety of calcium sensitive proteins. Calcium channels are known to play an important role in stimulating muscle contraction, in neurotransmitter secretion, gene regulation, activating other ion channels, controlling the shape and duration of action potentials and many other processes. Since calcium plays an integral role in cell function, and since excessive quantities can be toxic, its movement is tightly regulated and controlled through a large variety of mechanisms.

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  1. School of Biomedical, Biomoleculer and Chemical Sciences, The University of Western Australia, Crawley, WA, 6009, Australia

    Ben Corry & Livia Hool

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  1. Ben Corry
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  1. Res. School of Biological Sciences, Australian National University, Canberra, ACT 0200, Australia

    Shin-Ho Chung

  2. Weill Medical College Dept. Physiology, Cornell University, 1300 York Avenue, New York, NY, 10021, USA

    Olaf S. Andersen

  3. Dept. of Elect. & Comp. Engi., University of British Columbia, MacLeod Bulding, Vancouver, BC, Canada

    Vikram Krishnamurthy

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Corry, B., Hool, L. (2007). Calcium Channels. In: Chung, SH., Andersen, O.S., Krishnamurthy, V. (eds) Biological Membrane Ion Channels. Biological And Medical Physics Biomedical Engineering. Springer, New York, NY. https://doi.org/10.1007/0-387-68919-2_7

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