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Orai Channels

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Studies of Epithelial Transporters and Ion Channels

Part of the book series: Physiology in Health and Disease ((PIHD))

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Abstract

The highly calcium-selective ion channels formed by the Orai proteins represent a principal route for the agonist-induced entry of extracellular calcium in non-excitable cells, a process that is necessary for the generation of the calcium signals involved in the initiation and regulation of a multitude of diverse cellular responses. Consequently, their expression and activities play a major role in the essential functions of a wide range of diverse epithelial tissues. In marked contrast to the voltage-gated calcium channels of excitable cells, the molecular components of these channels (the Orai proteins) and their activation and regulation were only identified a little over 13 years ago. Because of this, there is still much to learn about the details of their unique biophysical properties, modes of activation, and functional roles.

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Acknowledgements

The studies reported here from the author’s laboratory were supported by NIH grant GM040557 to TJS. The excellent technical assistance of Ms. Jill Thompson is also acknowledged.

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  1. Department of Pharmacology and Physiology, University of Rochester Medical Center, New York, USA

    Trevor J. Shuttleworth

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  1. Trevor J. Shuttleworth
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Correspondence to Trevor J. Shuttleworth .

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  1. Department of Physiology, School of Biomedical Sciences, University of Otago, Dunedin, Otago, New Zealand

    Kirk L. Hamilton

  2. Department of Cell Biology, University of Pittsburgh, Pittsburgh, PA, USA

    Daniel C. Devor

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Shuttleworth, T.J. (2020). Orai Channels. In: Hamilton, K.L., Devor, D.C. (eds) Studies of Epithelial Transporters and Ion Channels. Physiology in Health and Disease. Springer, Cham. https://doi.org/10.1007/978-3-030-55454-5_26

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