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Portal Hypertension in the 21st Century

The proceedings of a symposium sponsored by Axcan Pharma Inc. and NicOx S.A., held in Montrél, Canada, April 2–4, 2004

  • Conference proceedings
  • © 2004

Overview

Editors:
  1. R. J. Groszmann

    1. Yale University School of Medicine, New Haven, USA

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  2. J. Bosch

    1. Hepatic Hemodynamic Laboratory Liver Unit, Hospital Clinic, University of Barcelona, Spain

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    You can also search for this editor in PubMed   Google Scholar

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Table of contents (35 papers)

  1. Front Matter

    Pages i-xviii
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  2. Introductory lectures

    1. Front Matter

      Pages 1-1
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    2. Portal hypertensive syndrome: its importance and complications

      • Andres T. Blei
      Pages 3-12

    3. The vascular endothelium and nitric oxide

      • John L. Wallace
      Pages 13-18

    4. Endothelial-derived nitric oxide as a marker for healthy endothelium

      • William C. Sessa
      Pages 19-23

  3. Mechanism of disease progression

    1. Front Matter

      Pages 25-25
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    2. Mechanisms of hepatic fibrogenesis

      • Scott L. Friedman
      Pages 27-35

    3. The role of hepatic stellate cells/myofibroblasts

      • Massimo Pinzani
      Pages 37-46

    4. Structural changes in the liver leading to cirrhosis and portal hypertension

      • Ian R. Wanless
      Pages 47-53

  4. Pathophysiology: increased resistance and increased blood flow

    1. Front Matter

      Pages 55-55
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    2. The paradox: vasoconstriction and vasodilation

      • Yasuko Iwakiri, Roberto J. Groszmann
      Pages 57-67

    3. Nitric-oxide-mediated vasodilation and portal hypertension

      • R. Wiest
      Pages 69-80

    4. Impaired vasodilation in cirrhotic livers

      • Mauricio R. Loureiro-Silva, Roberto J. Groszmann
      Pages 81-88

    5. Enhanced release of vasoconstrictors

      • Juan Carlos García-Pagán
      Pages 89-96

    6. Endogenous cannabinoids and circulatory dysfunction in cirrhosis

      • Wladimiro Jimënez, Josefa Ros
      Pages 97-101

  5. Mini-symposium: Possibilities of manipulating NO biosynthesis in the treatment of portal hypertension

    1. Front Matter

      Pages 103-103
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    2. NCX-1000: a liver-specific NO donor

      • Stefano Fiorucci, Elisabetta Antonelli, Antonio Morelli
      Pages 105-110

    3. Possibilities of manipulating nitric oxide biosynthesis in the treatment of portal hypertension: statins

      • Juan G. Abraldes, Carmen Zafra, J. Bosch
      Pages 111-120

    4. Pathophysiological role of Akt and endothelial nitric oxide synthase in cirrhosis

      • Manuel Morales-Ruiz
      Pages 121-126

    5. Nitric oxide synthase gene transfer

      • June Sung Lee, Vijay Shah
      Pages 127-131
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Keywords

About this book

Portal hypertension is the most important complication of a great variety of both acute and chronic liver diseases. Nevertheless, hepatic cirrhosis is the most frequent cause of portal hypertension. Gastrointestinal bleeding due to rupture of oesophageal varices is, without doubt, the most severe complication of portal hypertension. At present, great advances are being made in the pathophysiology and in the development of new therapeutic tools for controlling and preventing this severe clinical event.

This book contains the papers presented and discussed during the Symposium on 'Portal Hypertension in the 21st Century', held in Montréal, Canada, in April 2004, and sponsored by Axcan Pharma Inc. and NicOx S.A. There are eight sections covering basic mechanisms, new drugs, prevention and current treatment of variceal bleeding, prevention of recurrent bleeding and hepatic hemodynamic monitoring.

An international faculty of authors have contributed chapters at an outstanding scientific level which will be vital reading for scientists and clinicians alike.

Editors and Affiliations

  • Yale University School of Medicine, New Haven, USA

    R. J. Groszmann

  • Hepatic Hemodynamic Laboratory Liver Unit, Hospital Clinic, University of Barcelona, Spain

    J. Bosch

Bibliographic Information

  • Book Title: Portal Hypertension in the 21st Century

  • Book Subtitle: The proceedings of a symposium sponsored by Axcan Pharma Inc. and NicOx S.A., held in Montrél, Canada, April 2–4, 2004

  • Editors: R. J. Groszmann, J. Bosch

  • DOI: https://doi.org/10.1007/978-94-007-1042-9

  • Publisher: Springer Dordrecht

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media Dordrecht 2004

  • Hardcover ISBN: 978-0-7923-8797-8Published: 17 August 2004

  • Softcover ISBN: 978-94-010-3774-7Published: 29 October 2012

  • eBook ISBN: 978-94-007-1042-9Published: 27 June 2011

  • Edition Number: 1

  • Number of Pages: XVIII, 370

  • Topics: Hepatology, Biomedicine general

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