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Impaired vasodilation in cirrhotic livers

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Portal Hypertension in the 21st Century

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Abstract

Similarly to other vascular systems, the intrahepatic circulation has an intrinsic mechanism of vascular tone control. In addition to humoral and neural factors intrahepatic vascular tone is modulated by local production of vasoactive substances with autocrine and paracrine effects. Although different liver cells are able to produce vasoactive substances that can modulate intrahepatic vascular tone, endothelial cells playa central role in this function. Interposed between the lumen and the contractile elements of the vessel wall, endothelial cells react to different intraluminal stimuli releasing vasoconstrictor and vasodilator substances to adjust vascular tone to a particular situation1.

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Author information

Authors and Affiliations

  1. Hemodynamic Hepatic Laboratory, VA Connecticut Healthcare System, Yale University School of Medicine, 111H — 950 Campbell Avenue, West Haven, CT, 06516, USA

    Mauricio R. Loureiro-Silva

  2. VA Connecticut Healthcare System, Hepatic Hemodynamic Laboratory/111J, 950 Campbell Avenue, West Haven, CT, 06516, USA

    Roberto J. Groszmann

Authors
  1. Mauricio R. Loureiro-Silva
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  2. Roberto J. Groszmann
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Editor information

Editors and Affiliations

  1. Yale University School of Medicine, New Haven, CT, USA

    R. J. Groszmann

  2. Hepatic Hemodynamic Laboratory Liver Unit, Hospital Clinic, University of Barcelona, Spain

    J. Bosch

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© 2004 Springer Science+Business Media Dordrecht

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Loureiro-Silva, M.R., Groszmann, R.J. (2004). Impaired vasodilation in cirrhotic livers. In: Groszmann, R.J., Bosch, J. (eds) Portal Hypertension in the 21st Century. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-1042-9_9

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  • DOI: https://doi.org/10.1007/978-94-007-1042-9_9

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-3774-7

  • Online ISBN: 978-94-007-1042-9

  • eBook Packages: Springer Book Archive

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