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The Use of Cellulose Membrane to Eliminate Burst Release from Intravaginal Rings

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Abstract

Burst release was observed when ethylene vinyl acetate copolymer (EVA) intravaginal rings were tested for progesterone release in our previous work (Helbling et al. Pharm Res. 31(3):795–808, 2014). Burst release is undesirable in controlled delivery devices because release is uncontrollable and higher levels of active pharmaceutical ingredient could lead to the occurrence of adverse effect. The present contribution is about the use of membranes to coat EVA rings to eliminate burst release. Physicochemical state of progesterone in uncoated rings and the solubility and diffusion coefficient in membrane were studied. Hormone delivery from several rings of different sizes was compared. A mathematical model was used to analyze the effects of membrane properties on delivery rate. No chemical interactions were detected between hormone and polymer. Hormone was mainly forming amorphous aggregates inside rings, and migration to membrane was not observed during storage. Diffusion coefficient was smaller in membrane (∼10−8 cm2 s−1) than in matrix (∼10−7 cm2 s−1). Zero-order release kinetics were obtained for coated rings, and release rate decreases as the thickness of the coat increases. Cellulose membrane successfully eliminates burst release and controls the delivery from EVA rings. The equations developed can be used to determine the appropriate coat thickness to produce specific release rate.

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Abbreviations

API:

Active pharmaceutical ingredient

DSC:

Differential scanning calorimetry

EVA:

Ethylene-vinyl acetate copolymer

FTIR:

Fourier-transform infrared spectroscopy

HPLC:

High-performance liquid chromatography

IR:

Infrared spectroscopy

PE:

Poly ethylene

PLGA:

Poly(lactic-co-glycolic acid)

SEM:

Scanning electron microscopy

THF:

Tetrahydrofuran

VA:

Vinyl acetate

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ACKNOWLEDGMENTS

The authors wish to express their gratitude to Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) and to Universidad Nacional del Litoral (UNL) of Argentine, for the financial support granted to this contribution.

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Authors and Affiliations

  1. Laboratorio de Química Fina, Instituto de Desarrollo Tecnológico para la Industria Química (INTEC), Universidad Nacional del Litoral and Consejo Nacional de Investigaciones Científicas y Técnicas (UNL-CONICET), CCT CONICET-SANTA FE, Ruta Nacional 168, Paraje El Pozo, 3000, Santa Fe, Argentina

    Ignacio M. Helbling, Juan C. D. Ibarra & Julio A. Luna

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  1. Ignacio M. Helbling
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  2. Juan C. D. Ibarra
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  3. Julio A. Luna
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Correspondence to Ignacio M. Helbling.

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Helbling, I.M., Ibarra, J.C.D. & Luna, J.A. The Use of Cellulose Membrane to Eliminate Burst Release from Intravaginal Rings. AAPS J 18, 960–971 (2016). https://doi.org/10.1208/s12248-016-9914-1

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