Skip to main content
SpringerLink
Log in

Oxidative stress and its effect on cell functional activity in Alzheimer’s disease

  • Published:
Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry Aims and scope Submit manuscript

Abstract

The review summarizes literature data on the importance of oxidative stress as one of the pathogenetic mechanisms in Alzheimer’s disease. Special attention is paid to the main specific and nonspecific ways of reactive oxygen species (ROS) generation in the course of the disease development. Generated ROS influence functional activity of cells, particularly, apoptosis and the mitotic cycle. Phosphorylation/dephosphorylation processes associated with intense phosphorylation of tau protein and mitosis-specific proteins play the nodal regulatory role in the cell. Alzheimer’s disease is accompanied by impairments of the regulatory functions of peptidyl-prolyl isomerases, particularly, Pin1 involved in maintaining a balanced state of phosphorylation/dephosphorylation processes. Taking into consideration the multifactorial impairment of the cell cycle control, this process should be considered from the viewpoint of the general state of metabolic processes, and oxidative stress has one of the key positions in aging.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Harman, D., Ann. N.-Y. Acad. Sci., 1996, vol. 786, pp. 321–336.

    CAS  Google Scholar 

  2. Dubinina, E.E., Produkty metabolizma kisloroda v funktsional’noi aktivnosti kletok (zhizn’ i smert’, sozidanie i razrushenie) (Products of Oxygen Metabolism in Cell Functional Activity: Life and Death, Creation and Degradation), Saint Petersburg: Meditsinskaya Pressa, 2006.

    Google Scholar 

  3. Halliwell, B., in Free Radical in the Brain. Aging, Neurological and Mental Disorders, Packer, L., Philipko, L., and Christen, Y., Eds., Berlin, N.-Y., London: Springer-Verlag, 1992, pp. 21–40.

  4. Men’schikova, E.B., Lankin, V.Z., Zenkov, N.K., Bondar’, I.A., Krugovykh, N.F., and Trufakin, V.A., Okislitel’nyi stress. Prooksidanty i antioksidanty (Oxidative Stress. Prooxidants and Antioxidants), Moscow: Slovo 2006.

    Google Scholar 

  5. Colton, C.A. and Gilbert, D.L., in Oxygen Radicals in Biol. and Med., Proc. 4-th Int. Congr. New York-London, 1988, pp.1005–1010.

    Google Scholar 

  6. Hardas, S.S., Sultana, R., Clark, A.M., Beckett, T.L., Szweda, L.I., Murphy, M.P., and Butterfield, D.A., Redox Biol., 2013, vol. 1, pp. 80–85.

    CAS  Google Scholar 

  7. Dubinina, E.E., Biochemistry (Moscow) Suppl. Series B: Biomedical Chemistry, 2007, vol. 1, no. 4, pp. 284–298.

    Google Scholar 

  8. Markesbery, W.R., Free Radic. Biol. Med., 1997, vol. 23, pp. 134–147.

    CAS  Google Scholar 

  9. Zhu, M., Gu, F., Shi, J., Hu, Y., and Zhao, Z., Free Radic. Biol. Med., 2008, vol. 45, pp. 1493–1499.

    CAS  Google Scholar 

  10. Gavrilova, S.I., Nevrologiya, 2004, vol. 6, no. 2, pp. 3–10.

    Google Scholar 

  11. Gavriolova, S.I., Klin. Farmakol. i Ter., 2002, vol. 11, no. 4, pp. 1–7.

    Google Scholar 

  12. Wolozin, B., Kellman, W., Ruosseau, P., Celesia, G.G., and Siegel, G., Arch. Neurol., 2000, vol. 57, pp. 1439–1443.

    CAS  Google Scholar 

  13. Casley, C.S., Canevari, L., Land, J.M., Clark, J.B., and Sharpe, M.A., J. Neurochem., 2002, vol. 80, pp. 91–100.

    CAS  Google Scholar 

  14. Moreira, P.I., Nunomura, M., Nakamura, M., Takeda, A., Shenk, J. C., Aliev, G., Smith, M.A., and Perry, G., Free Radic. Biol. Med., 2008, vol. 44, pp. 1493–1505.

    CAS  Google Scholar 

  15. Picklo, M.J., Azenkeng, A., and Hoffmann, M.R., Free Radic. Biol. Med., 2011, vol. 50, pp. 400–407.

    CAS  Google Scholar 

  16. Revett, T.J., Baker, G.B., Jhamandas, J., and Kar, S., J. Psychiat. Neurosci., 2013, vol. 38, pp. 6–23.

    Google Scholar 

  17. Huang, X., Atwood, C. S., Hartshorn, M.A., Multhaup, G., Goldstein, L.E., Scarpa, R.C., Cuajungco, M.P., Gray, D.N., Lim, J., Moir, R.D., Tanzi, R.E., and Bush, A.I., Biochemistry, 1999, vol. 38, pp. 7609–7616.

    CAS  Google Scholar 

  18. Duce, J., Progr. Neurobiol., 2010, vol. 92, pp. 1–18.

    CAS  Google Scholar 

  19. Yang, C-A, Yung-Han Chen, Shyue-Chu Ke, Yi-Ru Chen, Hsien-Bin Huang, Ta-Hsien Lin, Yi-Cheng Chen, Int. J. Alzheimers Disease, 2011, vol. 2011, pp. 1–7.

    Google Scholar 

  20. Salvador, G.A., Uranga, R.M., and Giusto, N.M., J. Alzheimers Dis., 2010, vol. 2011, pp. 1–9.

    Google Scholar 

  21. Smith, M.A., Zhu, X., and Tabaton, M., J. Alzheimers Disease, 2010, vol. 19, pp. 363–372.

    Google Scholar 

  22. Deibel, M.A., Ehmann, W.D., and Markesberry, W.R., J. Neurol. Sci., 1996, vol. 143, pp. 137–142.

    CAS  Google Scholar 

  23. Wan, L., Nie, G., Zhang, J., Luo, Y., Zhang, P., Zhang, Z., and Zhao, B., Free Radic. Biol. Med., 2011, vol. 50, pp. 122–129.

    CAS  Google Scholar 

  24. Gutteridge, J.M.C., Quinlan, G.J., Clark, I.A., and Halliwell, B., Biochim. Biophys. Acta, 1985, vol. 835, pp. 441–447.

    CAS  Google Scholar 

  25. Kawahara, M. and Kato-Negishi, M., Int. J. Alzheimers Dis., 2011, vol. 2011, pp. 1–11.

    Google Scholar 

  26. Stewart, V.C. and Heales, S.J.R., Free Radic. Biol. Med., 2003, vol. 34, pp. 287–303.

    CAS  Google Scholar 

  27. Green, P.S., Mendez, A.J., Jacob, J.S., Crowley, J.R., Growdon, W., Hyman, B.T., and Heinecke, J.W., J. Neurochem., 2004, vol. 90, pp. 724–733.

    CAS  Google Scholar 

  28. Beal, M.F., Neurobiol. Aging, 2005, vol. 26, pp. 585–586.

    CAS  Google Scholar 

  29. Mao, P., Advances Biol. Chem., 2012, vol. 2, pp. 176–190.

    CAS  Google Scholar 

  30. Butterfield, D.A., Chem. Res. Toxicol., 1997, vol. 10, pp. 495–506.

    CAS  Google Scholar 

  31. Stepanichev, M.Yu., Moiseeva, Yu.V., and Gulyaeva, N.V., Neurokhimiya, 2002, vol. 19, no. 3, pp. 165–175.

    CAS  Google Scholar 

  32. Smith, M.A., Casadesus, G., Joseph, J.A., and Perry, G., Free Radic. Biol. Med., 2002, vol. 33, pp. 1194–1199.

    CAS  Google Scholar 

  33. Smith, M.A., Rudnicka-Nawrot, M., Richey, P.L., Praprotnik, D., Mulvihill, P., Miller, C.A., Sayre, L.M., and Perry, G., J. Neurochem., 1995, vol. 64, pp. 2660–2666.

    CAS  Google Scholar 

  34. Eshchenko, N.D., Biokhimiya psikhicheskikh i nervnykh boleznei (Biochemistry of Psychiatric and Nervous Diseases), Saint Petersburg: Saint Petersburg University, 2004.

    Google Scholar 

  35. Belkacemi, A. and Ramassamy, C., Free Radic. Biol. Med., 2012, vol. 52, pp. 593–600.

    CAS  Google Scholar 

  36. Ward, R.V., Jennings, K.N., Jepras, R., Neville, W., Owen, D.E., Hawkins, J., Chtistie. G., Davis, G.B., George, A., Karran, E.H., and Howlett, D.R., Biochem. J., 2000, vol. 348, pp. 137–144.

    CAS  Google Scholar 

  37. Ferriera, S.T., Vieira, M.N., and de Felice, F.S., IUBMB Life, 2007, vol. 59, pp. 332–345.

    Google Scholar 

  38. Resende, R., Ferreiro, E., and Pereira, S., Neuroscience, 2008, vol. 155, pp. 725–737.

    CAS  Google Scholar 

  39. Oda, N., Wals, P., Osterburg, H.H., Johnson, S.A., Pasinetty, G.M., Morgan, T.E., Rozovsky, I., Stine, W.V., Snyder, S.W., and Holzman, T.F., Exp. Neurol., 1995, vol. 136, pp. 22–31.

    CAS  Google Scholar 

  40. Butterfield, D.A., Reed, T., Newman, S.F., and Sultana, R., Free Radic. Biol. Med., 2007, vol. 43, pp. 658–677.

    CAS  Google Scholar 

  41. Butterfield, D.A. and Boyd-Kimball, D., Biochim. Biophys. Acta, 2005, vol. 1703, pp. 149–156.

    CAS  Google Scholar 

  42. Murray, I.V., Sindoni, M.E., and Axelsen, P.H., Biochemistry, 2005, vol. 44, pp. 12606–12613.

    CAS  Google Scholar 

  43. Butterfield, D.A., Galvan, V., Lange, M.B., Tang, H., Sowell, R.A., Spilman, P., Fombonne, J., Gorostiza, O., Zhang, J., Sultana, R., Bredesen, D.E., Free Radic. Biol. Med., 2010, vol. 48, pp. 136–144.

    CAS  Google Scholar 

  44. Miller, B., Williams, T., and Schoneich, C., Chem. Soc., 1996, vol. 118, pp. 11014–11025.

    CAS  Google Scholar 

  45. Moskovitz, J., Berlett, B.S., Poston, J.M., and Stadtman, E.R., Methods Enzymol., 1999, vol. 300, pp. 239–244.

    CAS  Google Scholar 

  46. Gabbita, S.P., Aksenov, M.Y., Lovell, M.A., and Markesbery, W.R., J. Neurochem., 1999, vol. 73, pp. 1660–1666.

    CAS  Google Scholar 

  47. Kanski, J., Aksenova, M., Schoneih, C., and Butterfield, D.A., Free Radic. Biol. Med., 2002, vol. 32, pp. 1205–1211.

    CAS  Google Scholar 

  48. Brot, N. and Weissbach, H., Arch. Biochem. Biophys., 1983, vol. 223, pp. 271–281.

    CAS  Google Scholar 

  49. Vogt, W., Free Radic. Biol. Med., 1995, vol. 18, pp. 93–105.

    CAS  Google Scholar 

  50. Zlokovic, B.V., Deane, R., Sallstrom, J., Chow, N., and Miano, J.M., Brain Pathol., 2005, vol. 15, pp. 78–83.

    CAS  Google Scholar 

  51. Owen, J.B., Sultana, R., Aluise, C.D., Erickson, M.A., Price, T.O., Bu, G., Banks, W.A., and Butterfield, D.A., Free Radic. Biol. Med., 2010, vol. 49, pp. 1798–1803.

    CAS  Google Scholar 

  52. Ma, W.W., Hou, C.C., Zhou, X., Yu, H.L., Xi, Y., Ding, J., Zhao, X., and Xiao, R., Neurochem. Res., 2013, vol. 38, pp. 1315–1323.

    CAS  Google Scholar 

  53. Deane, R., Bell, R.D., Sagare, A., and Zlokovic, B.V., CNS Neurol. Disord Drug Targets, 2009, vol. 8, pp. 16–30.

    CAS  Google Scholar 

  54. Liu, Q., Zerbinatti, C.V., Zhang, C.V., Hoe, H.S., Wang, B., Cole, S.L., Herz, J., Muglia, L., and Bu, G., Neuron, 2007, vol. 56, pp. 66–78.

    CAS  Google Scholar 

  55. Willnow, T.E., Rohlmann, A., Horton, J., Otani, H., Braun, J.R., Hammer, R.E., and Herz, J., EMBO J., 1996, vol. 15, pp. 2632–2639.

    CAS  Google Scholar 

  56. Jeynes, B. and Provias, J., Curr. Alzheimer Res., 2008, vol. 5, pp. 432–437.

    CAS  Google Scholar 

  57. Chen, X. and Yan, S.D., IUBMB Life, 2006, vol. 58, pp. 686–694.

    CAS  Google Scholar 

  58. Sayre, L.M., Perry, G., Harris, P.L., Liu, Y., Schubert, K.A., and Smith, M.A., J. Neurochem., 2000, vol. 74, pp. 270–279.

    CAS  Google Scholar 

  59. Smith, M.A., Harris, P.L.R., Sayre, L.M., and Perry, G., Proc. Natl. Acad. Sci., USA, 1997, vol. 94, pp. 9866–9868.

    CAS  Google Scholar 

  60. Brunk, U.T., Jones, C.B., and Sohal, R.S., Mutat. Res., 1992, vol. 275, pp. 395–403.

    CAS  Google Scholar 

  61. Smith, M.A., Perry, G., Richey, P.L., Sayre, L.M., Anderson, V.E., Beal, M.F., and Kowall, N., Nature, 1996, vol. 382, pp. 120–121.

    CAS  Google Scholar 

  62. Atwood, C.S., Perry, G., Zeng, H., Kato, Y., Jones, W.D., Ling, K. Q., Huang, X., Moir, R.D., Wang, D., Sayre, L.M., Smith, M.A., Chen, S.G., and Bush, A.I., Biochemistry (Moscow), 2004, vol. 43, pp. 560–568.

    CAS  Google Scholar 

  63. Chauhan, V. and Chauhan, A., Pathophysiology, 2006, vol. 13, pp. 195–208.

    CAS  Google Scholar 

  64. Nunomura, A., Perry, G., Aliev, G., Hirai, K., Takeda, A., Balraj, E.K., Jones, P.K., Ganbari, H., Wataya, T., Shimochama, S., Chiba, S., Atwood, C.S., Petersen, R.B., and Smith, M.A., J. Neuropathol. Exp. Neurol., 2001, vol. 60, pp. 759–767.

    CAS  Google Scholar 

  65. Smith, M.A., Joseph, J.A., and Perry, G., Ann. N.-Y. Acad. Sci., 2000, vol. 924, pp. 35–38.

    CAS  Google Scholar 

  66. Nunomura, A., Perry, G., Pappolla, M.A., Friedland, R.P., Hirai, K., Chiba, S., and Smith, M.A., J. Neuropathol. Exp. Neurol., 2000, vol. 59, pp. 1011–1017.

    CAS  Google Scholar 

  67. Cuajungco, M.P., Goldstein, L.E., Nunomura, A., Smith, M.A., Lim, J.T., Atwood, C.S., Huang, X., Farrag, Y.W., Perry, G., and Bush, A.I., J. Biol. Chem., 2000, vol. 275, pp. 19439–19442.

    CAS  Google Scholar 

  68. Pike, C.J., Walencewicz, A.J., Glabe, C.G., and Cotman, C.W., Eur. J. Pharmacol., 1991, vol. 207, pp. 367–368.

    CAS  Google Scholar 

  69. Davis, D.G., Schmitt, F.A., Eckstein, D.R., and Markesbery, W.R., J. Neuropathol. Exp. Neurol., 1999, vol. 58, pp. 376–388.

    CAS  Google Scholar 

  70. Walter, M.F., Mason, P.E., and Mason, R.P., Biochem. Biophys. Res. Commun., 1997, vol. 233, pp. 760–764.

    CAS  Google Scholar 

  71. Jang, J.-H. and Surh, Y.-J., Free Radic. Biol. Med., 2003, vol. 34, pp. 1100–1110.

    CAS  Google Scholar 

  72. Rottkamp, C.A., Raina, A.K., Zhu, X., Gaier, E., Bush, A.I., Atwood, C.S., Chevion, M., Perry, G., and Smith, M.A., Free Radic. Biol. Med., 2001, vol. 30, pp. 447–450.

    CAS  Google Scholar 

  73. Sultana, R., Boyd-Kimball, D., Poon, H.F., Cai, J., Pierce, W.M., Klein, J.B., Merchant, M., Markesbery, W.R., and Butterfield, D.A., Neurobiol. Aging, 2006, vol. 27, pp. 1564–1576.

    CAS  Google Scholar 

  74. Butterfield, D.A., Castegna, A., Laudeback, C.M., and Drake, J., Neurobiol. Aging, 2002, vol. 23, pp. 655–664.

    Google Scholar 

  75. Suzuki, Y.J., Forman, H.J., and Sylvanian, A., Free Radic. Biol. Med., 1997, vol. 22, pp. 269–285.

    CAS  Google Scholar 

  76. Butterfield, D.A., Abdul, H.M., Opii, W., Newman, S.F., Joshi, G., Ansari, M.A., and Sultana, R., J. Neurochem., 2006, vol. 98, pp. 1697–1706.

    CAS  Google Scholar 

  77. Delobe, P., Flament, S., Hamdane, M., Mailliot, C., Sambo, A.V., Sergeant, N., Delacourte, A., Vilain, J.-P., and Buee, L., J. Neurochem., 2002, vol. 83, pp. 412–420.

    Google Scholar 

  78. Buée, L., Bussiére, T., Buée-Scherre, V., Delacourte, A., and Hof, P.R., Brain Research Reviews, 2000, vol. 33, pp. 95–130.

    Google Scholar 

  79. Grunde-Iqbal, I., Iqbal, K., Tung, Y.C., Quinlan, M., Wisniewski, H.M., and Binder, L.I., Proc. Natl. Acad. Sci. USA, 1986, vol. 83, pp. 4913–4917.

    Google Scholar 

  80. Santa-Maria, I., Varghese, M., Ksizak-Reding, H., Dzhun, A., Wang, J., and Pasinetti, G.M., J. Biol. Chem., 2012, vol. 287, pp. 20522–20533.

    CAS  Google Scholar 

  81. Ksizak-Reding, H., Liu, W.K., and Yen, S.H., Brain Res., 1992, vol. 597, pp. 209–219.

    Google Scholar 

  82. Igbal, K., Gong, C.-X., and Liu, F., Front Neurol., 2013, vol. 4, pp. 112–121.

    Google Scholar 

  83. Illenberger, S., Zheng-Fishhofer, Q., Preuss, U., Stamer, K., Baumann, K., Trinzek, B., Biemat, J., Godemann, R., Mandelkow, E., and Mandelkow, E.M., Mol. Biol. Cell, 1998, vol. 9, pp. 1495–1512.

    CAS  Google Scholar 

  84. Chesser, A.S., Prichard, S.M., and Johnson, G.V.W., Front Neurol., 2013, vol. 4, pp. 122–126.

    Google Scholar 

  85. Lu, P.J., Wulf, G., Zhou, X.Z., Davies, P., and Lu, K.P., Nature, 1999, vol. 399, pp. 784–788.

    CAS  Google Scholar 

  86. Pastorino, L., Sun, A., Lu, P.J., Zhou, X.Z., Balastik, M., Finn, G., Wulf, G., Lim, J., Li, S.H., Li, X., Xia, W., Nicholson, L.K., and Lu, K.P., Nature, 2006, vol. 440, pp. 528–534.

    CAS  Google Scholar 

  87. Joseph, J.D., Yeh, E.S., Swenson, K.I., Means, A.R., and Winkler, Progr. Cell Cycle Res., 2003, vol. 5, pp. 477–487.

    Google Scholar 

  88. Kuboki, S., Sakai, N., Clarke, C., Schuster, R., Blanchard, J., Edwards, M.J., and Lentsch, A.B., J. Hepatol., 2009, vol. 51, pp. 296–306.

    CAS  Google Scholar 

  89. Cenini, G., Sultana, R., Memo, M., and Buttefield, D.A., Free Radic. Biol. Med., 2008, vol. 45, pp. 81–85.

    CAS  Google Scholar 

  90. Buschmann, T., Potapova, O., Bar-Shira, A., Ivanov, V.N., Fuchs, S.Y., Henderson, S., Fried, V.A., Alarcon-Vargas, D., Pincus, M.R., Gaarde, W.A., Holbrook, N.J., Shiloh, Y., and Ronai, Z., Mol. Cell. Biol., 2001, vol. 21, pp. 2743–2754.

    CAS  Google Scholar 

  91. Tamagno, E., Papola, M., Guglielmotto, M., Santoro, G., Bardini, P., Marra, L., Tabaton, M., and Danni, O., Free Radic. Biol. Med., 2003, vol. 35, pp. 45–58.

    CAS  Google Scholar 

  92. Andrieu-Abadie, N., Gouaze, V., Salvayre, R., and Levade, T., Free Radic. Biol. Med., 2001, vol. 31, pp. 2041–2048.

    Google Scholar 

  93. Ayasolla, K., Khan, M., Singh, A.K., and Singh, I., Free Radic. Biol. Med., 2004, vol. 37, pp. 325–338.

    CAS  Google Scholar 

  94. Popova, M.S. and Stepanichev, M.Yu., Neurokhimiya, 2008, vol. 25, no. 3, pp. 170–178.

    CAS  Google Scholar 

  95. Vincent, I., Rosado, M., and Davies, P., J. Cell Biology, 1996, vol. 132, pp. 413–425.

    CAS  Google Scholar 

  96. Vincent, I., Zheng, J.H., Dickson, D.W., Kress, Y., and Davies, P., Neurobiol. Aging, 1998, vol. 19, pp. 287–296.

    CAS  Google Scholar 

  97. Vincent, I., Pae, C.I., and Hallows, J.L., Progr. Cell Cycle Res., 2003, vol. 5, pp. 31–41.

    Google Scholar 

  98. Currais, A., Hortobagyi, T., and Soriano, S., Aging, 2009, vol. 1, pp. 363–369.

    CAS  Google Scholar 

  99. Ogawa, O., Lee, H.G., Zhu, X., Raina, A., Harris, P.L., Castellani, R.J., Perry, G., and Smith, M.A., Aging Cell, 2003, vol. 2, pp. 105–110.

    CAS  Google Scholar 

  100. Yang, Y., Geldmacher, D.S., and Herrap, K., J. Neurosci., 2001, vol. 21, pp. 2661–2668.

    CAS  Google Scholar 

  101. Nagy, Z., Esiri, M.M., Cato, A.M., and Smith, A.D., Acta Neuropathol., 1997, vol. 94, pp. 6–15.

    CAS  Google Scholar 

  102. Vincent, I., Bu, B., Hudson, K., Husseman, J., Nochlin, D., and Jin, L.-W., Neurosci., 2001, vol. 105, pp. 639–650.

    CAS  Google Scholar 

  103. Barrera, G., Pizzimenti, S., Laurora, S., Mononi, E., Giglioni, B., and Dianzan, M.U., Biochem. Biophys. Res. Commun., 2002, vol. 295, pp. 267–275.

    CAS  Google Scholar 

  104. Ranganathan, S., Scudiere, S., and Bowser, R., J. Alzheimers Dis., 2001, vol. 3, pp. 377–385.

    CAS  Google Scholar 

  105. Barrera, G., Pizzimenti, S., Muraca, R., Barbiero, G., Bonelli, G., Baccino, F., Fazio, V.M., and Dianzani, M.U., Free Radic. Biol. Med., 1996, vol. 20, pp. 455–462.

    CAS  Google Scholar 

  106. Dubinina, E.E. and Dadali, V.A., Biochemistry (Moscow), 2010, vol. 75, pp. 1189–1212.

    Google Scholar 

  107. Tomashevski, A., Husseman, J., Jin, L.W., Nochlin, D., and Vincent, L., Alzheimers Dis., 2001, vol. 3, pp. 195–207.

    CAS  Google Scholar 

  108. Ding, X.L., Husseman, J., Tomashevski, A., Nochlin, D., Jin, L.W., and Vincent, L., Am. J. Pathol., 2000, vol. 157, pp. 1983–1990.

    CAS  Google Scholar 

  109. Kesavapany, S., Patel, V., Zheng, H., Pareek, T.K., Bjelogrlic, M., Albers, W., Amin, N., Jaffe, H., Gutkind, J.S., Strong, M.J., Grant, P., and Pant, H.C., Mol. Biol. Cell, 2007, vol. 18, pp. 3645–3655.

    CAS  Google Scholar 

  110. Ma, S.L., Pastorino, L., Zhou, X.Z., and Lu, K.P., 2012, vol. 287, pp. 6969–6973.

  111. Ryo, A., Nakamura, M., Wulf, G., Liou, Y.C., and Lu, K.P., Nat. Cell Biol., 2001, vol. 3, pp. 793–801.

    CAS  Google Scholar 

  112. Thorpe, J.R., Morley, S.J., and Rulten, S.L., J. Histochem. Cytochem., 2001, vol. 49, pp. 97–108.

    CAS  Google Scholar 

  113. Zheng, H., You, H., Zhou, Y.Z., et al., Nature, 2002, vol. 419, pp. 849–853.

    CAS  Google Scholar 

  114. Bayer, E., Goettsch, S., Mueller, J.W., Griewel, B., Guiberman, E., Mayr, L.M., and Bayer, P., J. Biol. Chem., 2003, vol. 278, pp. 26183–26193.

    CAS  Google Scholar 

  115. Joseph, J.D., Yeh, E.S., Swenson, K.I., and Means, A.R., Progr. Cell Cycle Res., 2003, vol. 5, p. 477–487.

    Google Scholar 

  116. Schmetsdorf, S., Gartner, U., and Arendt, T., Cereb. Cortex., 2007, vol. 17, pp. 1821–1829.

    Google Scholar 

  117. Arendt, T., Rodel, L., Gartner, U., and Holzer, H., Neuroreport, 1996, vol. 7, pp. 3047–3049.

    CAS  Google Scholar 

  118. McShea, A., Harris, P.L., Webster, K.R., Wahl, A.F., and Smith, M.A., Am. J. Pathol., 1997, vol. 150, pp. 1933–1939.

    CAS  Google Scholar 

  119. Arendt, T., Holzer, M., and Gartner, U., J. Neural Transm., 1998, vol. 105, pp. 949–960.

    CAS  Google Scholar 

  120. Ogawa, O., Zhu, X., Lee, H.-G., Raina, A., Obrenovich, M.E., Bowser, R., Ghanbari, H.A., Castellani, R.J., Perry, G., and Smith, M.A., Acta Neuropathol., 2003, vol. 105, pp. 524–528.

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Bekhterev St. Peterburg Psychoneurological Research Institute, ul. Bekhtereva 3, Saint Petersburg, 193019, Russia

    E. E. Dubinina, L. V. Schedrina, N. G. Neznanov, N. M. Zalutskaya & D. V. Zakharchenko

Authors
  1. E. E. Dubinina
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. L. V. Schedrina
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. N. G. Neznanov
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. N. M. Zalutskaya
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. D. V. Zakharchenko
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to E. E. Dubinina.

Additional information

Original Russian Text © E.E. Dubinina, L.V. Schedrina, N.G. Neznanov, N.M. Zalutskaya, D.V. Zakharchenko, 2014, published in Biomeditsinskaya Khimiya.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Dubinina, E.E., Schedrina, L.V., Neznanov, N.G. et al. Oxidative stress and its effect on cell functional activity in Alzheimer’s disease. Biochem. Moscow Suppl. Ser. B 8, 181–191 (2014). https://doi.org/10.1134/S1990750814030044

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S1990750814030044

Keywords

Search

Navigation