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The interleukin-10 gene promoter polymorphism −1087AG does not correlate with clinical outcome in non-Hodgkin's lymphoma

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Abstract

The Interleukin 10 (IL-10) gene is highly polymorphic, and the IL-10−1087AG (rs1800896) gene variation is the only so far studied intensively in association with certain diseases. Conflicting data have been published about an association of IL-10−1087AG gene variation with lower rates of complete remission and lower overall survival (OS) in patients with diffuse large B-cell lymphoma. To further investigate this in malignant lymphoma, we established the IL-10 genotypes in patients from the NHL-B1/ B2 studies from the German High-Grade Non-Hodgkin's Lymphoma Study Group. In our study, allele frequencies of lymphoma patients are comparable as in healthy controls. No increase of IL-10–1087G alleles was found. In addition we did not find any difference in OS or event-free survival between patients with IL-10–1087AA and the other genotypes. Comparable results were obtained for the IL-10 loci at −3538 (A/T), −1354 (A/G), −824 (C/T) and −597 (A/C) (rs1800890, rs1800893, rs1800871 and rs1800872).

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Acknowledgements

The authors are gratefull to the Deutsche Forschnugsgemeinschaft (Graduiertenkolleg 1034), the BMBF (NGFN-1) and the Deutsche Krebshilfe/BMBF (NHL-B) for supporting this work.

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Authors and Affiliations

  1. Department of Hematology and Oncology, Universitätsmedizin der Georg-August-Universität, Göttingen, Germany

    D Kube, T-D Hua & L Trümper

  2. Department of Statistics and Epidemiology, Institute of Medical Informatics, University of Leipzig, Leipzig, Germany

    M Klöss & M Löffler

  3. Institute of Epidemiology, Universitätsmedizin der Georg-August-Universität, Göttingen, Germany

    B Kulle

  4. Section of Statistics, Institute of Basic Medical Science, University of Oslo, Oslo, Norway

    B Kulle

  5. Department of Pharmacology and Toxicology, Universitätsmedizin der Georg-August-Universität, Göttingen, Germany

    J Brockmöller & L Wojnowski

  6. Institute of Pharmacology, University Mainz, Mainz, Germany

    L Wojnowski

  7. Department of Internal Medicine I, Saarland University, Homburg/Saar for the DSHNHL (German High Grade NHL study group), Mainz, Germany

    M Pfreundschuh

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  1. D Kube
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  2. T-D Hua
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  3. M Klöss
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  4. B Kulle
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  5. J Brockmöller
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  6. L Wojnowski
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  7. M Löffler
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  8. M Pfreundschuh
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  9. L Trümper
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Correspondence to D Kube.

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Kube, D., Hua, TD., Klöss, M. et al. The interleukin-10 gene promoter polymorphism −1087AG does not correlate with clinical outcome in non-Hodgkin's lymphoma. Genes Immun 8, 164–167 (2007). https://doi.org/10.1038/sj.gene.6364364

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  • DOI: https://doi.org/10.1038/sj.gene.6364364

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