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Association of Interleukin-10 −3575T>A and −1082A>G polymorphisms with non-Hodgkin lymphoma susceptibility: a comprehensive review and meta-analysis

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Abstract

A number of studies have investigated the associations between IL-10 polymorphisms and non-Hodgkin lymphoma (NHL) susceptibility; however, the conclusions were still contradictory. To acquire a more precise estimation of the association, we performed the current meta-analysis. We systematically searched publications from EMBASE and MEDLINE, and calculated pooled odds ratios (ORs) and 95 % confidence intervals (CIs) using either fixed-effects or random-effects model. Genotype-based IL-10 mRNA expression analysis was performed using online public database of 270 individuals with three different ethnicities. A total of 10,703 cases and 11,823 controls from 10 studies were included for the −3575T>A polymorphism, 10,226 cases and 12,215 controls from 17 studies for the −1082A>G polymorphism. Pooled results indicated that IL-10 −3575T>A was associated with increased risk of diffuse large B cell lymphoma (DLBCL) and follicular lymphoma (FL), especially for Caucasians and hospital-based population. There was no association between IL-10 −1082A>G and NHL risk. However, subgroup analysis showed that IL-10 −1082GG might confer increased susceptibility to FL. In summary, this meta-analysis indicated that −3575T>A polymorphism was associated with altered NHL susceptibility for Caucasians and hospital-based population, especially for DLBCL and FL subtypes. The −1082A>G polymorphism may contribute to increased FL risk. Further large-scale population studies among different ethnicities are needed to validate these results.

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Acknowledgments

This study was funded by the grant from the National Natural Science Foundation of China (81101676) and Special Financial Grant from the China Postdoctoral Science Foundation (Grant No. 2014T70836).

Conflict of interest

The authors, Yan Zhang, Zu-Guang Xia Jin-Hong, Zhu, Min-Bin Chen, Tong-Min Wang, Wen-Xiang Shen, and Jing He, declare no conflicts of interest.

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This article does not contain any studies with human participants or animals performed by any of the authors.

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    Authors and Affiliations

    1. Department of Medical Oncology, Kunshan First People’s Hospital Affiliated to Jiangsu University, Kunshan, 215300, Jiangsu, China

      Yan Zhang, Min-Bin Chen & Wen-Xiang Shen

    2. Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, 510623, Guangdong, China

      Jing He

    3. State Key Laboratory of Oncology in South China, Department of Experimental Research, Sun Yat-sen University Cancer Center, Collaborative Innovation Center for Cancer Medicine, Guangzhou, 510060, Guangdong, China

      Tong-Min Wang & Jing He

    4. Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China

      Zu-Guang Xia

    5. Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China

      Zu-Guang Xia

    6. Molecular Epidemiology Laboratory and Laboratory Medicine, Harbin Medical University Cancer Hospital, Harbin, 150040, Heilongjiang, China

      Jin-Hong Zhu

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    Correspondence to Wen-Xiang Shen or Jing He.

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    Communicated by S. Hohmann.

    Y. Zhang and Z.-G. Xia contributed equally to this work and should be considered as co-first authors.

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    Zhang, Y., Xia, ZG., Zhu, JH. et al. Association of Interleukin-10 −3575T>A and −1082A>G polymorphisms with non-Hodgkin lymphoma susceptibility: a comprehensive review and meta-analysis. Mol Genet Genomics 290, 2063–2073 (2015). https://doi.org/10.1007/s00438-015-1058-y

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