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The Influence of Interleukin-2 Gene Polymorphisms on the Risk and Clinical Outcome of Non-Hodgkin Lymphoma

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Indian Journal of Hematology and Blood Transfusion Aims and scope Submit manuscript

Abstract

Polymorphisms in the IL-2 gene are associated with various diseases and cancers including non-Hodgkin lymphoma (NHL). The aim of the study is to assess the impact of IL-2 genetic polymorphisms [− 330 T/G (rs2069762) and + 114 T/G (rs2069763)] on the susceptibility and prognosis of NHL. Sixty patients with NHL as well as 60 age and sex matched healthy control subjects are included in this study. IL-2 genotypes were determined by Polymerase Chain Reaction-Restriction Fragment length Polymorphism assay (PCR–RFLP). Our study revealed that both IL-2 rs2069762 and rs2069763 gene polymorphisms are associated with increased risk of developing NHL; OR = 3.609 (95% CI = 1.527–8.417) and 4.142 (95% CI = 1.637–10.538) respectively. Moreover, the simultaneous presence of both polymorphisms is associated with about 6 fold increased risk of developing NHL. Also, IL-2 rs2069762 and rs2069763 gene polymorphisms increase the risk of unfavorable prognosis with OR = 17.300 (95% CI = 3.392–87.725) and 10.424(95% CI = 1.870–58.413) respectively. These findings suggest that IL-2 (rs2069762) and (rs2069763) gene polymorphisms could be involved in the development of NHL.

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References

  1. Nieters A, Conde L, Slager SL, Brooks-Wilson A, Morton L, Skibola DR et al (2012) PRRC2A and BCL2L11 gene variants influence risk of non-hodgkin lymphoma: results from the Interlymph consortium. Blood 120(23):4645–4648

    Article  CAS  Google Scholar 

  2. Skibola CF, Curry JD, Nieters A (2007) Genetic susceptibility to lymphoma. Haematologica 92:960–969

    Article  CAS  Google Scholar 

  3. Cerhan JR, Wang S, Maurer MJ, Ansell SM, Geyer SM, Cozen W et al (2007) Prognostic significance of host immune gene polymorphisms in follicular lymphoma survival. Blood 109(12):5439–5446

    Article  CAS  Google Scholar 

  4. Shen Y, Liu Y, Liu S, Zhang A (2012) The association between-330T/G polymorphism of interleukin 2 gene and bladder cancer. DNA Cell Biol 31(6):983–987

    Article  CAS  Google Scholar 

  5. Togawa S, Joh T, Itoh M, Katsuda N, Ito H, Matsuo K et al (2005) Interleukin-2 gene polymorphisms associated with increased risk of gastric atrophy from Helicobacter pylori infection. Helicobacter 10(3):172–178

    Article  CAS  Google Scholar 

  6. Matesanz F, Delgado C, Fresno M, Alcina A (2000) Allelic selection of human IL-2 gene. Eur J Immunol 30(12):3516–3521

    Article  CAS  Google Scholar 

  7. Wei YS, Lan Y, Zhang L, Wang JC (2010) Association of the interleukin-2 polymorphisms with interleukin-2 serum levels and risk of nasopharyngeal carcinoma. DNA Cell Biol 29(7):363–368

    Article  CAS  Google Scholar 

  8. Shin WG, Jang JS, Kim HS, Kim SJ, Kim KH, Jang MK et al (2008) Polymorphisms of interleukin-1 and interleukin-2 genes in patients with gastric cancer in Korea. J Gastroenterol Hepatol 23(10):1567–1573

    Article  CAS  Google Scholar 

  9. Peng Q, Li H, Lao X, Deng Y, Chen Z, Qin X et al (2014) Association of IL-2 polymorphisms and IL-2 serum levels with susceptibility to HBV-related hepatocellular carcinoma in a Chinese Zhuang population. Infect Genet Evol 27:375–381

    Article  CAS  Google Scholar 

  10. Sobjanek M, Zabłotna M, Bień E, Gleń J, Sokołowska-Wojdyło M, Ruckemann-Dziurdzińska K et al (2016) Clinical significance of IL-2 and IL-10 gene polymorphisms and serum levels in patients with basal-cell carcinoma. Biomark Med 10(2):185–195

    Article  CAS  Google Scholar 

  11. Hu XB, Ouyang LZ, Tang LL (2013) Interleukin-2 gene polymorphisms and prognosis of breast cancer. Genet Test Mol Biomark 17(6):453–457

    Article  CAS  Google Scholar 

  12. Swerdlow SH, Campo E, Pileri SA, Harris NL, Stein H, Siebert R et al (2016) The 2016 revision of the World Health Organization classification of lymphoid neoplasms. Blood 127(20):2375–2390

    Article  CAS  Google Scholar 

  13. Armitage JO (2005) Staging non-hodgkin lymphoma. CA Cancer J Clin 55(6):368–376

    Article  Google Scholar 

  14. Oken MM, Costello WG, Johnson GJ, Lenhard RE, Ezdinli EZ, Orlow E et al (1983) The influence of histologic subtype on toxicity and response to chemotherapy in non-hodgkin’s lymphoma. An eastern cooperative oncology group study utilizing the BCVP regimen. Cancer 5(9):1581–1586

    Article  Google Scholar 

  15. Zhuang H, Shen J, Zheng Z, Luo X, Gao R, Zhuang X (2014) MicroRNA-146a rs2910164 polymorphism and the risk of diffuse large B cell lymphoma in the Chinese Han population. Med Oncol 31(12):306

    Article  Google Scholar 

  16. Song H, Chen L, Cha Z, Bai J (2012) Interleukin 2 gene polymorphisms are associated with non-hodgkin lymphoma. DNA Cell Biol 31(7):1279–1284

    Article  CAS  Google Scholar 

  17. Ye X, Zhao K, Wu C, Hu P, Fu H (2017) Associations between genetic variants in immunoregulatory genes and risk of non-hodgkin lymphoma in a Chinese population. Oncotarget 8(6):10450–10457

    Article  Google Scholar 

  18. Howell WM, Rose-Zerilli MJ (2007) Cytokine gene polymorphisms, cancer susceptibility, and prognosis. J Nutr 137(1 Suppl):194S-199S

    Article  CAS  Google Scholar 

  19. Zhang M, Tan X, Huang J, Xie L, Wang H, Shi J et al (2016) Association between two interleukin-2 gene polymorphisms and cancer susceptibility: a meta-analysis. Onco Targets Ther 9:2181–2192

    Article  CAS  Google Scholar 

  20. Abdel Rahman HA, Khorshied MM, Reda Khorshid OM, Mourad HM (2018) Association of Interleukin-2-330T/G and interleukin-10-1082A/G genetic polymorphisms with B-cell non-hodgkin lymphoma in a cohort of egyptians. Turk J Haematol 35(2):99–108

    Article  CAS  Google Scholar 

  21. Nedoszytko B, Olszewska B, Roszkiewicz J, Glen J, Zabłotna M, Ługowska-Umer H et al (2016) The role of polymorphism of interleukin-2, −10, −13 and TNF-α genes in cutaneous T-cell lymphoma pathogenesis. Postepy Dermatol Alergol 33(6):429–434

    Article  Google Scholar 

  22. Lech-Maranda E, Baseggio L, Bienvenu J, Charlot C, Berger F, Rigal D et al (2004) Interleukin-10 gene promoter polymorphisms influence the clinical outcome of diffuse large B-cell lymphoma. Blood 103(9):3529–3534

    Article  CAS  Google Scholar 

  23. Juszczynski P, Kalinka E, Bienvenu J, Woszczek G, Borowiec M, Robak T et al (2002) Human leukocyte antigens class II and tumor necrosis factor genetic polymorphisms are independent predictors of non-hodgkin lymphoma outcome. Blood 100(8):3037–3040

    Article  Google Scholar 

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Authors and Affiliations

  1. Clinical Pathology Department, Kasr Al-Ainy School of Medicine, Cairo University, Cairo, 11562, Egypt

    Somaia Mohammed Mousa & Manal Mohamed Makhlouf

  2. Egyptian Ministry of Health, Cairo, Egypt

    Ekhlass Talaat Mohammed

  3. Clinical Oncology Department, Kasr Al-Ainy School of Medicine, Cairo University, Cairo, Egypt

    Hamdy Mohamed Zawam

Authors
  1. Somaia Mohammed Mousa
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  2. Manal Mohamed Makhlouf
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  3. Ekhlass Talaat Mohammed
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  4. Hamdy Mohamed Zawam
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Contributions

Study design and supervision of the work were performed by S.M.M., M.M.M. Medical practice and sample collection were performed by H.M.Z., E.T.M. Genotyping was done by M.M.M., E.T.M. Data analysis, procession and interpretation of the results were performed by S.M.M., M.M.M., E.T.M. The manuscript was written by S.M.M., M.M.M. All authors approved the final manuscript.

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Correspondence to Somaia Mohammed Mousa.

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The study protocol was approved by the Institutional Review board of Kasr Al-Ainy School of Medicine, Cairo University.

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Informed consent was provided prior to patient enrolment.

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Mousa, S.M., Makhlouf, M.M., Mohammed, E.T. et al. The Influence of Interleukin-2 Gene Polymorphisms on the Risk and Clinical Outcome of Non-Hodgkin Lymphoma. Indian J Hematol Blood Transfus 37, 549–554 (2021). https://doi.org/10.1007/s12288-020-01388-4

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  • DOI: https://doi.org/10.1007/s12288-020-01388-4

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