Direct conversion of adult Huntington’s disease patient fibroblasts into medium spiny neurons recapitulates hallmark phenotypes such as cell death, in contrast to models that lack epigenetic markers of aging. This successful ‘disease-in-a-dish’ highlights the benefits of capturing age in an adult-onset disorder model.
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Mattis, V.B., Svendsen, C.N. Huntington modeling improves with age. Nat Neurosci 21, 301–303 (2018). https://doi.org/10.1038/s41593-018-0086-4
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DOI: https://doi.org/10.1038/s41593-018-0086-4
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