Abstract
There are few historical records concerning Gregor Johann Mendel and his work, so theories abound concerning his motivation. These theories range from Fisher’s view that Mendel was testing a fully formed previous theory of inheritance to Olby’s view that Mendel was not interested in inheritance at all, whereas textbooks often state his motivation was to understand inheritance. In this Perspective, we review current ideas about how Mendel arrived at his discoveries and then discuss an alternative scenario based on recently discovered historical sources that support the suggestion that Mendel’s fundamental research on the inheritance of traits emerged from an applied plant breeding program. Mendel recognized the importance of the new cell theory; understanding of the formation of reproductive cells and the process of fertilization explained his segregation ratios. This interest was probably encouraged by his friendship with Johann Nave, whose untimely death preceded Mendel’s first 1865 lecture by a few months. This year is the 200th anniversary of Mendel’s birth, presenting a timely opportunity to revisit the events in his life that led him to undertake his seminal research. We review existing ideas on how Mendel made his discoveries, before presenting more recent evidence.
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References
Mendel, G. Versuche über Pflanzen-hybriden. Verh. Ver. Brünn 4, 3–47 (1866).
Correns, C. Gregor Mendel’s briefe an Carl Nägeli 1866-1873. Abh. Math.-Phys. Kl., K. Sächs. Ges. Wiss, 29, 189–265 (1905).
Fisher, R. A. Has Mendel’s work been rediscovered? Ann. Sci. 1, 115–137 (1936).
Van Dijk, P. J., Weissing, F. J. & Ellis, T. H. N. How Mendel’s interest in inheritance grew out of plant improvement. Genetics 210, 347–355 (2018).
Van Dijk, P. J. & Ellis, T. H. Mendel’s journey to Paris and London: context and significance for the origin of genetics. Folia Mendeliana 56, 5–33 (2020).
Unger, F. Botanische Briefe (C. Gerold & Sohn, 1852).
Mendel, G. Experiments on Plant Hybrids (trans Müller-Wille, S. & Hall, K., British Society for the History of Science Translation Series) http://www.bshs.org.uk/bshs-translations/mendel.BSHS (2016).
Orel, V. Gregor Mendel: The First Geneticist (Oxford University Press, 1996).
Klein, J. & Klein, N. Solitude of a Humble Genius - Gregor Johann Mendel: Volume 1: Formative Years (Springer-Verlag, 2013).
Gärtner, C. F. Versuche und Beobachtungen über die Bastarderzeugung im Pflanzenreich (Hering, 1849).
Olby, R. C. Origins of Mendelism 2nd ed (University of Chicago Press, 1985).
Fisher, R. A. The Genetical Theory of Natural Selection 1st ed (Oxford University Press, 1930).
De Beer, G. Mendel, Darwin and Fisher (1865–1965). Notes Rec. R. Soc. 19, 192–226 (1964).
Dunn, L. C. Mendel, his work and his place in history. Proc. Am. Philos. Soc. 109, 189–198 (1965).
Mayr, E. The Growth of Biological Thought (Harvard University Press, 1982).
Olby, R. C. Mendel no Mendelian? Hist. Sci. 17, 57–72 (1979).
Gasking, E. B. Why was Mendel’s work ignored? J. Hist. Ideas 20, 60–84 (1959).
Orel, V. & Hartl, D. L. Controversies in the interpretation of Mendel’s discovery. Hist. Philos. Life Sci. 16, 423–464 (1994).
Monaghan, F. & Corcos, A. F. The real objective of Mendel’s paper. Biol. Philos. 5, 267–292 (1990).
Fairbanks, D. J. Mendel and Darwin: untangling a persistent enigma. Heredity 124, 263–273 (2020).
Franklin, A. & Laymon, R. Once Can Be Enough. Decisive Experiments, No Replication Required (Springer Nature, 2021).
Gliboff, S. in Outsider Scientists: Routes to Innovation in Biology (eds. Harman, O. & Dietrich, M.R.) 27–44 (Univ. Chicago Press, 2013).
Müller-Wille, S. in Handbook of the Historiography of Biology (ed Dietrich, M.) (Springer International Publishing, 2018).
Mendel, G. Über Verwüstung im Gartenrettich durch Raupen (Botys margaritalis). Verh. Zool.-Bot. Verein. Wien. 3, 116–168 (1853).
Mendel, G. Über Bruchus pisi, mitgeteilt von V. Kollar. Verh. Zool.-Bot. Verein. Wien. 4, 27–28 (1854).
Eichling, C. I talked with Mendel. J. Hered. 33, 243–246 (1942).
Beadle, G. W. in Heritage from Mendel (eds Brink, R. A. & Styles, E. D.) 335–350 (Univ. Wisconsin Press, 1967).
Knight, T. A. An account of some experiments on the fecundation of vegetables. Philos. Trans. R. Soc. Lond. 89, 195–204 (1799).
Wellensiek, S. J. Erwten toen en nu in Honderd jaar Mendel (Pudoc, Centrum voor Landbouwpublikaties en Landbouwdocumentatie, 1965).
Ellis, T. H. N., Hofer, J. M. I., Swain, M. T. & Van Dijk, P. J. Mendel’s pea crosses: varieties, traits and statistics. Hereditas 156, 33 (2019).
Seton, A. On the variation in the colour of peas from cross-impregnation. Trans. Horticultural Soc. Lond. 5, 236 (1824).
Goss, J. On the variation in the colour of peas, occasioned by cross-impregnation. Trans. Horticultural Soc. Lond. 5, 234 (1824).
Laxton, T. Observations on the Variations Effected by Crossing in the Colour and Character of the Seed of Peas (International Horticultural Exhibition and Botanical Congress, 1866).
Laxton, T. Notes on some changes and variations in the offspring of cross-fertilized peas. J. R. Hortic. Soc. 3, 10–14 (1872).
Giltay, E. Ueber den directen Einfluss des Pollens auf Frucht und Samenbildung. Pringsh. Jahrb. Wiss. Bot. 25, 489–506 (1895).
Pasteur, L. Discours prononcé à Douai, le 7 décembre 1854, à l’occasion de l’installation solennelle de la Faculté des lettres de Douai et de la Faculté des sciences de Lille in Oeuvres de Pasteur (ed Pasteur Vallery-Radot, P.) 131 (Masson and Co., 1939).
Harris, H. The Birth of the Cell (Yale Univ. Press, 1999).
Churchill, F. B. August Weissmann (Harvard Univ. Press, 2015).
Schleiden, M. J. Einige Blicke auf die Entwicklungsgeschichte des vegetabilischen Organismus bei den Phanerogamen. Arch. Naturgesch. 3, 289–414 (1837).
Radlkofer, L. Die Befruchtung der Phanerogamen: Ein Beitrag zur Entscheidung des darüber bestehenden Streites (Engelmann, 1856).
Strasburger, E. Neue Untersuchungen über den Befruchtungsvorgang bei den Phanerogamen, als Grundlage für eine Theorie der Zeugung (Jena Gustav Fischer, 1884).
Nave, J. Ueber die Entwicklung und Fortpflanzung der Algen. Aufsätze. Jahresheft der naturwissenschaftlichen Section der schlesischen Gesellschaft für Ackerbau für das Jahr 1858, 86–101 (Rohrer, 1859).
Iltis, H. Gregor Johann Mendel: Leben, Werk und Wirkung (Springer, 1924).
Kalmus, J. Skizze von dem Leben und Wirken des verstorbenen J. Nave. Verh. Ver. Brünn 3, 82–85 (1865).
Piternick, L. K. & Piternick, G. Gregor Mendel’s Letters to Carl Nägeli. Genetics 35, 1–29 (1950).
Nägeli, C. Die Bastardbildung im Pflanzenreiche, Sitzungsberichte der Königl. Bayer 2, 395–443 (Akademie der Wissenschaften, 1865).
Van Dijk, P. J. & Ellis, T. H. N. Mendel’s reaction to Darwin’s provisional hypothesis of pangenesis and the experiment that could not wait. Heredity https://doi.org/10.1038/s41437-022-00546-w (2022).
Darbishire, A. D. Breeding and the Mendelian Discovery (Cassell & Co., 1911).
Acknowledgements
We are very grateful to B. O. Bengtsson, J. Hofer, M. de Both and P. van Baarlen for critically reading and commenting on draft versions of the manuscript. T.H.N.E. gratefully acknowledges receipt of an Institute Strategic Fellowship from the John Innes Centre. P.J.v.D. thanks KeyGene for providing a supportive environment for research into the early history of genetics.
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P.J.v.D., A.P.J. and T.H.N.E. wrote the manuscript. All authors critically read and edited the manuscript.
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van Dijk, P.J., Jessop, A.P. & Ellis, T.H.N. How did Mendel arrive at his discoveries?. Nat Genet 54, 926–933 (2022). https://doi.org/10.1038/s41588-022-01109-9
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DOI: https://doi.org/10.1038/s41588-022-01109-9
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