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Requirement for Xist in X chromosome inactivation

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Abstract

The Xist gene has been proposed as a candidate for the X inactivation centre, the master regulatory switch locus that controls X chromosome inactivation. So far this hypothesis has been supported solely by indirect evidence. Here we describe gene targeting of Xist, and provide evidence for its absolute requirement in the process of X chromosome inactivation.

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Author information

Author notes

  1. Graham F. Kay

    Present address: Queensland Institute of Medical Research, The Bancroft Centre, 300 Herston Road, Brisbane, Q4029, Australia

  2. Sohaila Rastan

    Present address: The Medical Research Council, 20 Park Crescent, London, WIN 4AL, UK

  3. Neil Brockdorff: To whom correspondence should be addressed.

Authors and Affiliations

  1. Section of Comparative Biology, MRC Clinical Sciences Centre, Royal Postgraduate Medical School, Hammersmith Hospital, Du Cane Road, London, W12 ONN, UK

    Graeme D. Penny, Graham F. Kay, Steven A. Sheardown, Sohaila Rastan & Neil Brockdorff

Authors
  1. Graeme D. Penny
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  2. Graham F. Kay
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  3. Steven A. Sheardown
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  4. Sohaila Rastan
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  5. Neil Brockdorff
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Penny, G., Kay, G., Sheardown, S. et al. Requirement for Xist in X chromosome inactivation. Nature 379, 131–137 (1996). https://doi.org/10.1038/379131a0

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  • DOI: https://doi.org/10.1038/379131a0

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