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Candidate proto-oncogene bcl-3 encodes a subunit-specific inhibitor of transcription factor NF-κB

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Abstract

THE NF-κB subunits pSO and p65 and the product of the rel proto-oncogene are members of a growing class of transcription factors with a unique DNA-binding and dimerization domain1–13. Nuclear transfer of each of these factors is controlled by cytoplasmic inhibitors, and regulated by specific stimuli. The inhibitors 1κB-α and -β and pp40 recognize either p65 or the c-rel protein14–16. We show here that the proto-oncogene bcl-3, believed to be involved in certain human B-cell leukaemias17, encodes a protein that functions as an IκB-like molecule for native NF-κB but is specific for the p50 subunit. The ankyrin repeat domain of the bcl-3 product is shown to mediate complex formation with NF-κB dimers by contacting the conserved dimerization domain of NF-κB.

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  1. Claus Scheidereit: To whom correspondence should be addressed.

Authors and Affiliations

  1. Otto Warburg Laboratorium, Max Planck Institut für Molekulare Genetik, Ihnestrasse 73, 1000, Berlin, 33, Germany

    F. Gregory Wulczyn, Michael Naumann & Claus Scheidereit

Authors
  1. F. Gregory Wulczyn
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  2. Michael Naumann
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  3. Claus Scheidereit
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Wulczyn, F., Naumann, M. & Scheidereit, C. Candidate proto-oncogene bcl-3 encodes a subunit-specific inhibitor of transcription factor NF-κB . Nature 358, 597–599 (1992). https://doi.org/10.1038/358597a0

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  • DOI: https://doi.org/10.1038/358597a0

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