Abstract
Nuclear factor kappa B (NFκB) is a group of structurally related transcription factors, including RelA (p65), RelB, c-Rel, NF-κB1 (p50 and precursor p105), and NF-κB2 (p52 and precursor p100) (Youn et al., Nutr Cancer 61:847–854, 2009). They form homodimers and heterodimers with different combinations when binding to their consensus DNA elements to regulate gene transcription at the promoters and enhancers. NFκB is active in many cellular processes and plays a key role in regulating innate and adaptive immune response, inflammation, proliferation, and cell death. Aberrant activation of NFκB and the signaling pathways that regulate its activity contributes to the carcinogenesis in most cancer sites and can be linked to tumor resistance to chemotherapy and radiotherapy (Baud and Karin, Nat Rev 8:33–40, 2009).
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Young, M.R., Hu, Y., Colburn, N.H. (2017). NF-κB. In: Marshall, J. (eds) Cancer Therapeutic Targets. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-0717-2_7
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DOI: https://doi.org/10.1007/978-1-4419-0717-2_7
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