Abstract
The vascular endothelium, in response to pulsatile flow and vaso-active agents including acetylcholine1,2, secretes the endothelium-derived relaxing factor (EDRF), a substance which regulates vascular tone. Recent interest in EDRF has focused on its possible dysfunction in atherosclerosis1. In animal models of the disease, endothelium-dependent relaxation is markedly reduced3,4. The continuous exposure of the endothelium in hyperlipidaemia to high concentrations of low-density lipoprotein (LDL), a known atherogenic risk factor, may explain this dysfunction. Here, we demonstrate that pathophysiological concentrations of LDL directly inhibit endothelium-dependent relaxation. Chemically modified LDL, in contrast, is inactive, implying that the inhibition is through a receptor-dependent mechanism.
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1. Vanhoutte, P. M., Rubanyi, G. M., Miller, V. M. & Houston, D. S. A. Rev. PhysioL 48, 307–320 (1986). 2. Furchgott, R. F. & Zawadzki, J. V. Nature 288, 373–376 (1980). 3. Coene, M.-C. et al. Br. J. Pharmac. 85, 267P (1985). 4. Ibengwe, J. K. & Suzuki, H. Br. J. Pharmac. 87, 395–402 (1986). 5. Chung, B. H., Wilkinson, T., Geer, J. C. & Segrest, J. P. /. Lipid Res. 21, 284–291 (1980). 6. Furchgott, R. F. Circulation Res. 53, 557–573 (1983). 7. Martin, W., Villani, G. M., Jothianandan, D. & Furchgott, R. F. /. Pharmac. exp. Ther. 232, 708–716 (1985). 8. Mahley, R. W. et al. J. biol. Chem. 252, 7279–7287 (1977). 9. Weisgraber, K. H., Innerarity, T. L. & Mahley, R. W. /. biol. Chem. 253, 9053–9062 (1978). 10. Roller, E., Quehenberger, O., Jurgens, G., Wolfbeis, O. S. & Esterbauer, H. FEES. Lett. 198, 229–234 (1986). 11. Furchgott, R. F., Jothianandan, D. & Cherry, P. D. in Vasodilator Mechanisms (eds Vanhoutte, P. M. & Vatner, S. F.) 1–15 (Karger, Basel, 1984). 12. Brown, M. S. & Goldstein, J. L. Proc. natn. Acad. Sci. U.S.A. 76, 3330–3337 (1979). 13. Kannell, W. B., Castelli, W. P., Gordon, T. & McNamara, P. M. Ann. intern. Med. 74, 1–12 (1971). 14. Poole, J. C. F., Sanders, A. G. & Florey, H. W. /. Path. Bact. 75, 133–143 (1958).
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Andrews, H., Bruckdorfer, K., Dunn, R. et al. Low-density lipoproteins inhibit endothelium-dependent relaxation in rabbit aorta. Nature 327, 237–239 (1987). https://doi.org/10.1038/327237a0
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DOI: https://doi.org/10.1038/327237a0
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