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Sensitivity of cytotoxic T cells to T-cell mediated cytotoxicity

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Abstract

LYMPHOID cells sensitised against alloantigens can lyse in vitro target cells bearing these alloantigens1,2. In most of the experimental systems using in vivo sensitised cells, T cells (thymus-dependent lymphocytes) are both necessary3 and sufficient4,5 for induction of target cell lysis. This seems to apply also to in vitro sensitised cells6–9. Specific cytolysis can be described as a two stage process: first, the recognition of target cell antigens by specific receptors at the surface of the ‘killing’ cell10,11; and, second, lysis itself.

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Authors and Affiliations

  1. Tumour Immunology Unit, Department of Zoology, University College London, Gower Street, London, WC1E 6BT, UK

    PIERRE GOLSTEIN

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  1. PIERRE GOLSTEIN
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GOLSTEIN, P. Sensitivity of cytotoxic T cells to T-cell mediated cytotoxicity. Nature 252, 81–83 (1974). https://doi.org/10.1038/252081a0

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  • DOI: https://doi.org/10.1038/252081a0

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