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Nitrosoguanidine mutagenesis during nuclear and mitochondrial gene replication

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A Corrigendum to this article was published on 11 October 1974

Abstract

The timing of individual nuclear gene replication during S phase in an eukaryote can now be studied by nitrosoguanidine mutagenesis. Using this technique, results also suggested that mitochondrial DNA replication is synchronous and a late event in the cell cycle.

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References

  1. Cerdà-Olmedo, E., Hanawalt, P. C., and Guerola, N., J. molec. Biol., 33, 705–719 (1968).

    Article  PubMed  Google Scholar 

  2. Guerola, N., Ingraham, J. L., and Cerdà-Olmedo, E., Nature, 230, 122–125 (1971).

    CAS  Google Scholar 

  3. Hohlfeld, R., and Vielmetter, W., Nature new Biol., 242, 130–132 (1973).

    Article  CAS  PubMed  Google Scholar 

  4. Williamson, D. H., in Cell Synchrony (edit. by Cameron, I. L., and Padilla, G. M.), 81–101 (Academic Press, New York and London, 1966).

    Book  Google Scholar 

  5. Carter, B. L. A., Sebastian, J., and Halvorson, H. O., Adv. Enzyme Regulation. 9, 253–263 (1971).

    Article  Google Scholar 

  6. Sebastian, J., Carter, B. L. A., and Halvorson, H. O., J. Bact., 108, 1045–1050 (1971).

    CAS  PubMed  PubMed Central  Google Scholar 

  7. Mortimer, R. K., and Hawthorne, D. C., Genetics, 74, 33–54 (1973).

    CAS  PubMed  PubMed Central  Google Scholar 

  8. Nordström, K., J. gen. Microbiol., 48, 277–281 (1967).

    Article  PubMed  Google Scholar 

  9. Williamson, D. H., Symp. Soc. exp. Biol., 24, 247–276 (1970).

    CAS  PubMed  Google Scholar 

  10. Faye, G., et al., Biochimie, 55 (in the press).

  11. Cottrell, S. F., and Avers, C. J., Biochem. biophys. Res. Commun., 38, 973–980 (1970).

    Article  CAS  PubMed  Google Scholar 

  12. Smith, D., Tauro, P., Schweizer, E., and Halvorson, H. O., Proc. natn. Acad. Sci. U.S.A., 60, 936–942 (1968).

    Article  ADS  CAS  Google Scholar 

  13. Williamson, D. H., and Moustacchi, E., Biochem. biophys. Res. Commun., 42, 195–201 (1971).

    Article  CAS  PubMed  Google Scholar 

  14. Thomas, D. Y., and Wilkie, D., Genet. Res., 11, 33–41 (1968).

    Article  CAS  PubMed  Google Scholar 

  15. Stuart, K. D., Biochem. biophys. Res. Commun., 39, 1045–1051 (1970).

    Article  CAS  PubMed  Google Scholar 

  16. Avner, P. R., Coen, D., Dujon, B., and Slonimski, P. P., Molec. gen. Genet., 125, 9–52 (1973).

    Article  CAS  PubMed  Google Scholar 

  17. Lee, R. W., and Jones, R. F., Molec. gen. Genet., 121, 99–108 (1973).

    Article  CAS  PubMed  Google Scholar 

  18. Mitchison, J. M., The Biology of the Cell Cycle (Cambridge University Press, 1971).

    Google Scholar 

  19. Mitchison, J. M., in The Cell Cycle in Development and Differentiation (edit. by Balls, M., and Billet, F. S.) 1–11 (Cambridge University Press, 1973).

    Google Scholar 

  20. Giles, K. W., and Myers, A., Nature, 206, 93 (1965).

    Article  ADS  CAS  Google Scholar 

  21. Ogur, M., St. John, R., and Nagai, S., Science, 125, 928–929 (1957).

    Article  ADS  CAS  PubMed  Google Scholar 

  22. Cerdà-Olmedo, E., and Hanawalt, P. C., Molec. gen. Genet., 101, 191–202 (1968).

    Article  PubMed  Google Scholar 

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Dawes, I., Carter, B. Nitrosoguanidine mutagenesis during nuclear and mitochondrial gene replication. Nature 250, 709–712 (1974). https://doi.org/10.1038/250709a0

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  • DOI: https://doi.org/10.1038/250709a0

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