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Immunoglobulin Determinants on the Surface of Mouse Lymphoid Cells

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Abstract

THERE is increasing evidence that lymphocytes have antigen-specific receptors on their surface1–3 and it seems reasonable to suppose that the receptors are immunoglobulins (Ig)1. The existence of Ig on the surface of lymphocytes has also been inferred from the transforming effect of anti-Ig sera4 and the opsonic adherence to macrophages of lymphocytes treated with anti-Ig5. We report here the demonstration of Ig determinants on the surface of living mouse lymphocytes by the use of immunofluorescence and immunoautoradiography.

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Authors and Affiliations

  1. National Institute for Medical Research, Mill Hill, London, NW7

    M. C. RAFF, M. STERNBERG & R. B. TAYLOR

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  1. M. C. RAFF
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  2. M. STERNBERG
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  3. R. B. TAYLOR
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RAFF, M., STERNBERG, M. & TAYLOR, R. Immunoglobulin Determinants on the Surface of Mouse Lymphoid Cells. Nature 225, 553–554 (1970). https://doi.org/10.1038/225553a0

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