Abstract
The behaviour of rats in a maze can be experimentally altered to a comparable extent either by psychoactive drugs or by previous experience of the maze. The effects of even a short drug/maze experience may stay with the organism “for life”.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Steinberg, H., Rushton, R., and Tinson, C., Nature, 192, 533 (1961).
Rushton, R., Steinberg, H., and Tinson, C., Brit. J. Pharmacol. Chemother., 20, 99 (1963).
Rushton, R., and Steinberg, H., Brit. J. Pharmacol. Chemother., 21, 295 (1963).
Rushton, R., and Steinberg, H., Neuropsychopharmacology, 15, 464 (1967).
Irwin, S., Slabok, M., and Thomas, G., J. Pharmacol. Exp. Ther., 123, 206 (1958).
Bradley, D. W. M., Joyce, D., Murphy, E. H., Nash, B. M., Porsolt, R. D., Summerfield, A., and Twyman, W. A., Nature, 220, 187 (1968).
Joyce, D., Porsolt, R. D., and Summerfield, A., Paper given to CINP meeting, Tarragona (1968).
Steinberg, H., and Watson, R. H. J., Nature, 185, 615 (1960).
Hinde, R. A., Proc. Roy. Soc., B, 153, 398 (1960).
Overton, D. A., Psychopharmacologia (Berlin), 10, 6 (1966).
Sachs, E., in Comparative Psychopathology: Animal and Human (edit. by Zubin, J., and Hunt, H. F.) (Grune and Stratton, New York, 1967).
Hughes, R. N., Anim. Behav., 16, 92 (1968).
Tanner, J. M., Growth and Adolescence (Blackwell, London, 1962).
Rushton, R., and Steinberg, H., in Animal Behaviour and Drug Action (edit. by Steinberg, H., de Reuck, A. V. S., and Knight, J.) (Churchill, London, 1964).
Stern, M. H., Canad. J. Psychol., 14, 96 (1960).
Ross, S., and Schnitzer, S. B., Psychol. Rep., 13, 461 (1963).
Cochin, J., and Kornetsky, C., J. Pharmacol. Exp. Ther., 145, 1 (1964).
Marriott, A. S., and Spencer, P. S., Brit. J. Pharmacol. Chemother., 25, 432 (1965).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
RUSHTON, R., STEINBERG, H. & TOMKIEWICZ, M. Equivalence and Persistence of the Effects of Psychoactive Drugs and Past Experience. Nature 220, 885–889 (1968). https://doi.org/10.1038/220885a0
Received:
Issue Date:
DOI: https://doi.org/10.1038/220885a0
- Springer Nature Limited
This article is cited by
-
The effects of repeated doses of ethanol on exploration and its habituation
Psychopharmacology (1987)
-
Dose-response effects of scopolamine on activity in an open field
Psychopharmacologia (1975)
-
Pharmacologically Induced Behavioural Supersensitivity to Apomorphine
Nature New Biology (1973)
-
Interaction between prior experience and the effects of chlorpromazine on exploration in the rat
Psychopharmacologia (1973)
-
Potentiation of the effects of chlorpromazine on exploration in the rat by a prior experience of the drug
Psychopharmacologia (1973)