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Proposed Physiological Function for Plasma Cholinesterase

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Abstract

THE physiological function of plasma, or non-specific, cholinesterase, although receiving some attention1, has not been established. This report deals with the possibility of its role as a regulator of free choline in the plasma. Several experiments were conducted in vitro to determine: (1) the inhibitory effects of free choline on the synthesis of acetylcholine and the activity of serum cholinesterase; (2) whether acetyl-S-coenzyme A (AcCoA) and choline acetylase were capable of synthesizing acetylcholine from another choline ester.

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Authors and Affiliations

  1. Division of Pharmacology, Ontario Veterinary College, University of Guelph, Canada

    H. S. FUNNELL

  2. Food and Drug Directorate, Tunney's Pasture, Ottawa, Canada

    W. T. OLIVER

Authors
  1. H. S. FUNNELL
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  2. W. T. OLIVER
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FUNNELL, H., OLIVER, W. Proposed Physiological Function for Plasma Cholinesterase. Nature 208, 689–690 (1965). https://doi.org/10.1038/208689a0

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