Skip to main content
SpringerLink
Log in

Stimulation of Mast Cell Production in Lymph Nodes of the Rat by Pyrrolizidine Alkaloids

  • Letter
  • Published:

From Nature

View current issue Submit your manuscript

Abstract

MAST cells are known to increase in some tissues under certain conditions often associated with an immunological component. Well-known examples are in the skin in the vicinity of induced epitheliomas in mice1 and associated with proliferative changes in the thymus of NZB mice2. In lymph nodes, where under normal conditions mast cells occur in small numbers only, Miller3 observed an increase in mast cell numbers after injection of Salmonella antigens, and Takeoka et al.4 noted a significant increase in mast cells in the lungs and mediastinal lymph nodes in rats being fed seeds of Crotalaria spectabilis or the pyrrolizidine alkaloid, monocrotaline, isolated from this plant.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Bloom, G. D., Ann. N.Y. Acad. Sci., 103, 53 (1963).

    Article  ADS  CAS  Google Scholar 

  2. Burnet, F. M., J. Path. Bact., 89, 271 (1965).

    Article  CAS  Google Scholar 

  3. Miller, J. J., III (personal communication).

  4. Takeoka, O., Angevine, D. M., and Lalich, J. J., Amer. J. Path., 40, 545 (1962).

    CAS  PubMed  Google Scholar 

  5. Culvenor, C. C. J., Dann, A. T., and Dick, A. T., Nature, 195, 570 (1962).

    Article  ADS  CAS  Google Scholar 

  6. Culvenor, C. C. J., Drummond, L. J., and Price, J. R., Austral. J. Chem., 7, 277 (1954).

    Article  CAS  Google Scholar 

  7. Culvenor, C. C. J., Austral. J. Chem., 7, 287 (1954).

    Article  CAS  Google Scholar 

  8. Bull, L. B., Dick, A. T., and McKenzie, J. S., J. Path. Bact., 75, 19 (1958).

    Article  Google Scholar 

  9. Bull, L. B., and Dick, A. T., J. Path. Bact., 78, 483 (1959).

    Article  CAS  Google Scholar 

Download references

Author information

Author notes

  1. E. DIENER: Supported by a Roche fellowship.

Authors and Affiliations

  1. Walter and Eliza Hall Institute for Medical Research, Royal Melbourne Hospital, Australia

    E. DIENER

  2. C.S.I.R.O. Division of Animal Health, Parkville, N.2, Victoria, Australia

    A. T. DICK

Authors
  1. E. DIENER
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. T. DICK
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

DIENER, E., DICK, A. Stimulation of Mast Cell Production in Lymph Nodes of the Rat by Pyrrolizidine Alkaloids. Nature 207, 1305–1306 (1965). https://doi.org/10.1038/2071305b0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/2071305b0

  • Springer Nature Limited

Search

Navigation