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Potential role of miR-100 in cancer diagnosis, prognosis, and therapy

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Tumor Biology

Abstract

MicroRNAs (miRNAs) are small non-coding RNAs that function by base pairing with messenger RNAs, thereby regulating protein expression. Functional studies indicate that miRNAs are involved in the regulation of almost every biological pathway. Moreover, changes in miRNA expression are associated with several human pathologies, including cancer. Dysregulation and aberrant expression of microRNA-100 (miR-100) have been reported to be involved in tumorigenesis and tumor progression of several cancer types, suggesting that miR-100 might serve as a diagnostic and/or prognostic marker for human malignancy. In this review, we summarize the potential application of miR-100 in cancer treatment and as a new molecular marker for cancer prognosis and diagnosis. We will provide a brief introduction to miR-100 and discuss its role as a non-invasive biomarker and a potential therapeutic target in human cancers.

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Acknowledgments

This work was supported by grants from the National Natural Science Foundation of China (No.81272601, 81472198), the Key Clinical Medicine Technology Foundation of Jiangsu Province (No.BL2014096), the Medical Key Talented Person Foundation of the Jiangsu Provincial Developing Health Project (No.RC2011080), Innovation Team Project of the Second Affiliated Hospital of Nanjing Medical University (No.CX201202), and “333 high class Talented Man Project” (No.2011-III-2630).

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    1. Department of Clinical Medicine, The First Medical college of Nanjing Medical University, Nanjing, 210029, Jiangsu, People’s Republic of China

      Chu Qin & Ru-Yi Huang

    2. Department of Oncology, The Second Affiliated Hospital, Nanjing Medical University, 121 Jiangjiayuan Road, Nanjing, 210011, Jiangsu, People’s Republic of China

      Zhao-Xia Wang

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    1. Chu Qin
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    Correspondence to Zhao-Xia Wang.

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    Chu Qin and Ru-Yi Huang contributed equally to this work.

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    Qin, C., Huang, RY. & Wang, ZX. Potential role of miR-100 in cancer diagnosis, prognosis, and therapy. Tumor Biol. 36, 1403–1409 (2015). https://doi.org/10.1007/s13277-015-3267-8

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