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The role of microRNA-196a in tumorigenesis, tumor progression, and prognosis

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Tumor Biology

Abstract

MicroRNAs are a large group of non-coding RNAs that have emerged as regulators of various biological processes, especially carcinogenesis and cancer progression. Recent evidence has shown that microRNA-196a (miR-196a) is upregulated in most types of tumors and involved in multiple biological processes via translational inhibition and mRNA cleavage, such as cell proliferation, migration, and invasion, mostly functioning as an oncogene. Dysregulation of miR-196a promotes oncogenesis and tumor progression. In this review, we summarize the upstream regulators, target genes, signaling pathways, and single nucleotide polymorphisms of miR-196a, which collectively affect cell proliferation, migration, and invasion. In addition, we review the clinical outcomes and significance of miR-196a. miR-196a may serve as a novel biomarker or target for diagnosis, prognosis, and therapy in several human cancers.

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Acknowledgments

This work was supported by grants from the National Natural Science Foundation of China (No.81272601, 81472198), the Key Clinical Medicine Technology Foundation of Jiangsu Province (No.BL2014096), the Medical Key Talented Person Foundation of the Jiangsu Provincial Developing Health Project (No.RC2011080), the Innovation Team Project of the Second Affiliated Hospital of Nanjing Medical University, and the “333 high class Talented Man Project” (No.2011-III-2630).

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  1. Department of Oncology, The Second Affiliated Hospital, Nanjing Medical University, 121 Jiangjiayuan Road, Nanjing, 210011, Jiangsu, China

    Zhen-Yao Chen, Xin Chen & Zhao-Xia Wang

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  1. Zhen-Yao Chen
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  2. Xin Chen
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Correspondence to Zhao-Xia Wang.

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Zhen-Yao Chen and Xin Chen contributed equally to this work.

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Chen, ZY., Chen, X. & Wang, ZX. The role of microRNA-196a in tumorigenesis, tumor progression, and prognosis. Tumor Biol. 37, 15457–15466 (2016). https://doi.org/10.1007/s13277-016-5430-2

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