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Emblica officinalis (amla) ameliorates arsenic-induced liver damage via DNA protection by antioxidant systems

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Abstract

Present study demonstrates the therapeutic role of Emblica officinalis (EO) against arsenic-induced DNA and hepatic damage in female rats. Our earlier study on arsenic-exposed human unveils a link between tissue necrosis and carcinogenesis with impaired antioxidant system-associated DNA damage. Here we show ingestion of EO extract (500 mg in 0.1 mL water) in combination with sodium arsenite (0.4 ppm)/100 g b.w. for 24 days to rats offered significant protection against arsenic-induced oxidative damages of DNA and hepatic tissue architecture. Arsenic only exposure decreased hepatic superoxide dismutase, catalase activities and the level of non protein soluble thiol with a concomitant increase in thiobarbituric acid reactive substances and conjugated di-enes which are restrained by EO with a restoration of antioxidant components. In conclusion, restricted generation of free radicals is correlated to DNA protection resulting in prevention of tissue necrosis and possible carcinogenesis.

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Author notes

  1. Amiya Kumar Hati

    Present address: Department of Pathology, Gautam Laboratories 9A, K. K. Street, Calcutta, 700 007, India

Authors and Affiliations

  1. Post Graduate Department of Biochemistry, Cell and Molecular Therapeutics Laboratory, Oriental Institute of Science and Technology, Vidyasagar University, Midnapore, 721102, West Bengal, India

    Smarajit Maiti & Nirmallya Acharyya

  2. Department of Bio-Medical Laboratory Science and Management, (UGC Innovative Department), Vidyasagar University, Midnapore, 721 102, West Bengal, India

    Sandip Chattopadhyay & Bimal Deb

  3. School of Tropical Medicine, Calcutta, India

    Amiya Kumar Hati

Authors
  1. Smarajit Maiti
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  2. Sandip Chattopadhyay
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  3. Nirmallya Acharyya
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  4. Bimal Deb
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  5. Amiya Kumar Hati
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Correspondence to Smarajit Maiti.

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Maiti, S., Chattopadhyay, S., Acharyya, N. et al. Emblica officinalis (amla) ameliorates arsenic-induced liver damage via DNA protection by antioxidant systems. Mol. Cell. Toxicol. 10, 75–82 (2014). https://doi.org/10.1007/s13273-014-0009-8

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  • DOI: https://doi.org/10.1007/s13273-014-0009-8

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