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Role of Neurochemicals in the Interaction between the Microbiota and the Immune and the Nervous System of the Host Organism

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Abstract

This work is concerned with the role of evolutionary conserved substances, neurotransmitters, and neurohormones, within the complex framework of the microbial consortium–immune system–nervous system axis in the human or animal organism. Although the operation of each of these systems per se is relatively well understood, their combined effects on the host organism still await further research. Drawing on recent research on host-produced and microbial low-molecular-weight neurochemicals such as biogenic amines, amino acids, and short-chain fatty acids (SCFAs), we suggest that these mediators form a part of a universal neurochemical “language.” It mediates the whole gamut of harmonious and disharmonious interactions between (a) the intestinal microbial consortium, (b) local and systemic immune cells, and (c) the central and peripheral nervous system. Importantly, the ongoing microbiota–host interactivity is bidirectional. We present evidence that a large number of microbially produced low-molecular-weight compounds are identical or homologous to mediators that are synthesized by immune or nervous cells and, therefore, can bind to the corresponding host receptors. In addition, microbial cells specifically respond to host-produced neuromediators/neurohormones because they have adapted to them during the course of many millions of years of microbiota–host coevolution. We emphasize that the terms “microbiota” and “microbial consortium” are to be used in the broadest sense, so as to include, apart from bacteria, also eukaryotic microorganisms. These are exemplified by the mycobiota whose role in the microbial consortium–immune system–nervous system axis researchers are only beginning to elucidate. In light of the above, it is imperative to reform the current strategies of using probiotic microorganisms and their metabolites for treating and preventing dysbiosis-related diseases. The review demonstrates, in the example of novel probiotics (psychobiotics), that many target-oriented probiotic preparations produce important side effects on a wide variety of processes in the host organism. In particular, we should take into account probiotics’ capacity to produce mediators that can considerably modify the operation of the microecological, immune, and nervous system of the human organism.

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Notes

  1. Tyrosine is synthesized in the human organism from phenylalanine, an essential amino acid that must be contained in food.

  2. High dopamine concentration, conversely, causes vasoconstriction [72].

  3. 5НТ5А receptors inhibit, and several other types of serotonin receptors activate, the intracellular adenylate cyclase enzyme.

  4. Estradiol is the most important hormone of the estrogen group that also includes estrone and estriol.

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Authors and Affiliations

  1. General Ecology Department, Biology School, Moscow State University, Vorobiev Hills, Moscow, 119991, Russia

    Alexander V. Oleskin

  2. Gabrichevsky Research Institute of Epidemiology and Microbiology, Moscow, Russia

    Boris A. Shenderov

  3. Pirogov Russian National Medical Research Institute, Moscow, Russia

    Vladimir S. Rogovsky

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  1. Alexander V. Oleskin
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  2. Boris A. Shenderov
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  3. Vladimir S. Rogovsky
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Correspondence to Alexander V. Oleskin.

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Oleskin, A.V., Shenderov, B.A. & Rogovsky, V.S. Role of Neurochemicals in the Interaction between the Microbiota and the Immune and the Nervous System of the Host Organism. Probiotics & Antimicro. Prot. 9, 215–234 (2017). https://doi.org/10.1007/s12602-017-9262-1

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