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Hematological and Biochemical Parameters in Apparently Healthy Indian Population: Defining Reference Intervals

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Abstract

Clinical reference intervals among Indian population are poorly defined. Therefore, there is an urgent need to establish local clinical laboratory reference intervals for healthy Indian population. The present study aimed to identify the 95 % reference interval for hematological and biochemical parameters in apparently healthy Indian population. We undertook a multicentric cross-sectional study conducted at Apollo Hospitals Educational and Research Foundation across India. Of which 10,665 reference individuals identified as healthy by physicians. The 95 % of the reference distribution was estimated using 2.5th and 97.5th percentile reference limits. The 95 % reference intervals for hemoglobin (Males: 12.3–17 g/dL; Females: 9.9–14.3 g/dL), platelet count (Males: 1.3–3.8; Females: 1.3–4.2 Lakhs/µL), erythrocyte sedimentation rate (Males: 2–22; Females: 4–55 mm/h), serum uric acid in males: 3.5–8.2 mg/dL, gamma glutamyl transferase (Males: 13–61 U/L), fasting blood glucose (Males: 78–110 mg/dL), total cholesterol (Males: 115–254 mg/dL), low density lipoprotein (Males: 60–176 mg/dL) and triglycerides (Males: 55–267 mg/dL, Females: 52–207 mg/dL) were different from currently used reference values. Additionally need for gender based partitioning were observed for triglycerides and gamma glutamyl transferase. The observed findings are of clinical significance and it needs to be validated with additional community based studies.

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Acknowledgments

We thank Prof. Ranjit Roy Chaudhury for his guidance and support. We also thank AHERF research team who helped for data collection and management. Our special thanks to Dr. Prathap C. Reddy, Ms. Shobana Kamineni and Mr. Sridhar for funding the project.

Conflict of Interest

The authors have declared that no competing interest exists.

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Authors and Affiliations

  1. Department of Internal Medicine and Rheumatology, Apollo First Med Hospital, Chennai, 600 010, India

    Shrilekha Sairam

  2. Department of Biochemistry & Therapeutic Drug Monitoring, Apollo Health City, Jubilee Hills, Hyderabad, 500 033, Andhra Pradesh, India

    Suhasini Domalapalli

  3. Apollo Hospitals Educational and Research Foundation (AHERF), No: 16 & 17, II Floor, Krishnadeep Chambers, Apollo Annexe, No 1, Wallace Garden, Thousand Lights, Chennai, 600 006, India

    Sundaram Muthu, Jayanthi Swaminathan & Vivek A. Ramesh

  4. Department of Internal Medicine, Indraprastha Apollo Hospitals, New Delhi, 110 076, India

    Lalitha Sekhar

  5. Health Checkup, Apollo Hospitals International Ltd., Ahmedabad, 382428, India

    Palak Pandeya

  6. Department of Preventive Health Checks, Apollo Group of Hospital, Chennai, 600 006, India

    Udhaya Balasubramaniam

Authors
  1. Shrilekha Sairam
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  2. Suhasini Domalapalli
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  3. Sundaram Muthu
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  4. Jayanthi Swaminathan
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  5. Vivek A. Ramesh
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  6. Lalitha Sekhar
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  7. Palak Pandeya
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  8. Udhaya Balasubramaniam
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Correspondence to Jayanthi Swaminathan.

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Sairam, S., Domalapalli, S., Muthu, S. et al. Hematological and Biochemical Parameters in Apparently Healthy Indian Population: Defining Reference Intervals. Ind J Clin Biochem 29, 290–297 (2014). https://doi.org/10.1007/s12291-013-0365-5

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  • DOI: https://doi.org/10.1007/s12291-013-0365-5

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