Abstract
An increase in the communication within the healthcare services, both nationally and internationally, has strengthened the need for harmonization of measurements and reference intervals in laboratory medicine. In the present report, the calculated reference interval for serum creatinine (sCr) levels of healthy normal individuals (n=1121) in different sex and age groups are compared with the established interval. The calculated reference interval for sCr level was 0.4–1.3 mg/dL and 0.6 to 1.3 mg/dL in the age groups of 21–40 and 41–60 years respectively. The difference between the mean sCr values in total males and total females (age range 21–60 years) was statistically significant (p<0.0001); When male and female subjects were analyzed age-group wise, the data showed a significant difference in mean sCr values (p<0.0001) in three age groups (21–30, 31–40 and 41–50 years) however, in older age group (51–60 years), the difference was non-significant (p=0.07). The reference ranges were 0.7–1.3 and 0.4–1.0 mg/dL for males and females respectively where the lower limit was 0.1–0.2 units less than that of standard limits. An increase in the mean value of sCr was observed particularly in females with an increase in age. Hence it is of interest to validate an age specific reference ranges for sCr in our population.
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Levey, A.S., Coresh, J., Balk, E., Kausz, A.T., Levin, A., Steffes, M.W., Hogg, R.J., Perrone, R.D., Lau, J. and Eknoyan, G. (2003) National Kidney Foundation practice guidelines for chronic kidney disease: evaluation, classification, and stratification. Ann. Intern. Med. 139, 137–147.
Burtis, C. A. and Ashwood, E.R. (1999) Establishment and use of reference values. In: Tietz Textbook of Clinical Chemistry, Chapter 14, 3rd edition W.B. Saunders Company, Philadelphia U.S.A. 336–356.
National Committee for Clinical Laboratory Standards: How to define, determine and utilize reference intervals in the clinical laboratory: Proposed guidelines (2000) 2nd ed., NCCLS document C28-A2, Villanova PA, NCCLS.
Perrone, R.D., Madias, N.E. and Levey, A.S. (1992) Serum creatinine as an index of renal function: new insights into old concepts. Clin. Chem. 38, 1933–1953.
Shemesh, O., Golbetz, H., Kriss, J.P. and Myers, B.D. (1985) Limitations of creatinine as a filtration marker in glomerulopathic patients. Kidney, Int. 28, 830–838.
Nilsson, S.E., Takkinen, S., Tryding, N., Evrin, P.E., Berg, S., McClearn, G. and Johansson, B. (2003) Association of biochemical values with morbidity in the elderly: a population-based Swedish study of persons aged 82 or more years. Scand. J. Clin. Lab. Invest. 63, 457–466.
Takabatake, T., Ohta, H., Ishida, Y., Hara, H., Ushiogi, Y. and Hattori, N. (1988) Low serum creatinine levels in severe hepatic disease. Arch. Intern. Med. 148, 1313–1315.
Levey, A.S., Perrone, R.D. and Madias N.E. (1988) Serum creatinine and renal function. Annu. Rev. Med. 39, 465–490.
Wu, A.H., Stout, R. and McComb, R.B. (1983) Falsely high serum creatinine concentration associated with severe methanol intoxication. Clin Chem. 29, 205–208.
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Verma, M., Khadapkar, R., Sahu, P.S. et al. Comparing age-wise reference intervals for serum creatinine concentration in a “Reality check” of the recommended cut-off. Indian J Clin Biochem 21, 90–94 (2006). https://doi.org/10.1007/BF02912919
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DOI: https://doi.org/10.1007/BF02912919