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Customized lipid-coated magnetic mesoporous silica nanoparticle doped with ceria nanoparticles for theragnosis of intracerebral hemorrhage

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Abstract

Intracerebral hemorrhage (ICH), caused by the sudden rupture of an artery within the brain, is a devastating subtype of stroke, which currently has no effective treatment. Intense inflammatory reactions that occur in the peri-hematomal area after ICH are more deleterious than the hematoma itself, resulting in subsequent brain edema and neurologic deterioration. Thus, we developed lipid-coated magnetic mesoporous silica nanoparticles doped with ceria nanoparticles (CeNPs), abbreviated as LMCs, which have both potent anti-inflammatory therapeutic effects via scavenging reactive oxygen species and help in increasing the efficacy of magnetic resonance imaging enhancement in the peri-hematomal area. LMCs consist of mesoporous silica nanoparticle-supported lipid bilayers, which are loaded with large amounts of CeNPs for scavenging of reactive oxygen species, and iron oxide nanoparticles for magnetic resonance imaging contrast. LMCs loaded with CeNPs exhibited strong anti-oxidative and anti-inflammatory activities in vitro. In the rodent ICH model, intracerebrally injected LMCs reached the peri-hematomal area and were engulfed by macrophages, which were clearly visualized by magnetic resonance imaging of the brain. Moreover, LMCs reduced inflammatory macrophage infiltration, and thus significantly reduced brain edema. Finally, LMC treatment markedly improved neurologic outcomes of the animals with ICH. Thus, LMC is the first nanobiomaterial that successfully showed theragnostic effects in ICH.

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Acknowledgements

This research was supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (No. HI17C0076), and also supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning (No. NRF-2015R1A2A2A01007770).

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Author notes

  1. Bong Geun Cha and Han-Gil Jeong contributed equally to this work.

Authors and Affiliations

  1. School of Chemical Engineering, Sungkyunkwan University, Suwon, 16419, Republic of Korea

    Bong Geun Cha, Myong-Joo Nam & Jaeyun Kim

  2. Department of Laboratory of Innovative Nanobiotechnology, Biomedical Research Institute, Seoul National University Hospital 101, Daehak-ro, Jongno-gu, Seoul, 03080, Republic of Korea

    Han-Gil Jeong, Dong-Wan Kang, Chi Kyung Kim, Do Yeon Kim, In-Young Choi, Seul Ki Ki, Song I. Kim, Ju hee Han & Seung-Hoon Lee

  3. Department of Neurology, Seoul National University Hospital 101, Daehak-ro, Jongno-gu, Seoul, 03080, Republic of Korea

    Han-Gil Jeong, Dong-Wan Kang, Do Yeon Kim, In-Young Choi, Seul Ki Ki, Song I. Kim, Ju hee Han & Seung-Hoon Lee

  4. Department of Neurology, Korea University Guro Hospital and Korea University College of Medicine, Seoul, 08308, Republic of Korea

    Chi Kyung Kim

  5. Department of Health Sciences and Technology, Samsung Advanced Institute for Health Science & Technology (SAIHST), Sungkyunkwan University, Suwon, 16419, Republic of Korea

    Jaeyun Kim

  6. Biomedical Institute for Convergence at SKKU (BICS), Sungkyunkwan University (SKKU), Suwon, 16419, Republic of Korea

    Jaeyun Kim

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  1. Bong Geun Cha
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Correspondence to Jaeyun Kim or Seung-Hoon Lee.

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12274_2017_1924_MOESM1_ESM.pdf

Customized lipid-coated magnetic mesoporous silica nanoparticle doped with ceria nanoparticles for theragnosis of intracerebral hemorrhage

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Cha, B.G., Jeong, HG., Kang, DW. et al. Customized lipid-coated magnetic mesoporous silica nanoparticle doped with ceria nanoparticles for theragnosis of intracerebral hemorrhage. Nano Res. 11, 3582–3592 (2018). https://doi.org/10.1007/s12274-017-1924-5

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