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Inhibitory effects of (−)-loliolide on cellular senescence in human dermal fibroblasts

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Abstract

Cellular senescence influences tumor suppression and progress, tissue repair and regeneration, tissue and organismal aging, and age-related diseases. Aging intervention might be an advantageous target for prevention and treatment of diverse age-related diseases. In this study, we investigated whether (−)-loliolide purified from the crude extract of Polygonum aviculare exerted inhibitory activity against cellular senescence in human dermal fibroblasts (HDFs). (−)-Loliolide diminished senescence-associated β-galactosidase activity (SA-β-gal), the level of p21 protein, and the level of reactive oxygen species in senescent cells induced by adriamycin treatment. (−)-Loliolide also attenuated SA-β-gal activity in HDFs under replicative senescence. These findings imply that (−)-loliolide rescues cellular senescence in HDFs and might be useful for the development of dietary supplements or cosmetics that ameliorate tissue aging or age-associated diseases.

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Acknowledgments

This work was supported by a National Research Foundation of Korea (NRF) grant funded by the Korean government (MEST) (2005-0049417).

Conflict of interest

The authors declare that they have no conflicts of interest.

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Authors and Affiliations

  1. Department of Biochemistry and Molecular Biology, College of Medicine, Yeungnam University, 170 Hyunchung-Ro, Daegu, 705-717, Republic of Korea

    Hyo Hyun Yang, Jung Hee Cho, Hwa Young Kim, Suk Hwan Baek & Jae-Ryong Kim

  2. Department of Physiology, College of Medicine, Yeungnam University, Daegu, 705-717, Republic of Korea

    So Young Park

  3. Department of Pharmacology, College of Medicine, Yeungnam University, Daegu, 705-717, Republic of Korea

    Hyung Chul Choi

  4. Aging-Associated Vascular Disease Research Center, College of Medicine, Yeungnam University, Daegu, 705-717, Republic of Korea

    Hyo Hyun Yang, Jung Hee Cho, Jong-Keun Son, Hwa Young Kim, Suk Hwan Baek, Hyung Chul Choi, So Young Park & Jae-Ryong Kim

  5. College of Pharmacy, Yeungnam University, Gyeongsan, 712-749, Republic of Korea

    Kyoung Hwangbo & Jong-Keun Son

  6. College of Pharmacy, Yanbian University, Yanji, 133000, People’s Republic of China

    Ming Shan Zheng

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  1. Hyo Hyun Yang
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  10. Jae-Ryong Kim
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Correspondence to Jae-Ryong Kim.

Additional information

Hyo Hyun Yang, Kyoung Hwangbo and Ming Shan Zheng have contributed equally to this work.

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Yang, H.H., Hwangbo, K., Zheng, M.S. et al. Inhibitory effects of (−)-loliolide on cellular senescence in human dermal fibroblasts. Arch. Pharm. Res. 38, 876–884 (2015). https://doi.org/10.1007/s12272-014-0435-0

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  • DOI: https://doi.org/10.1007/s12272-014-0435-0

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