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Microwave-Assisted Extraction of Methyl β-Cyclodextrin-Complexed Curcumin from Turmeric Rhizome Oleoresin

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Abstract

In this work, methyl β-cyclodextrin (Mβ-CD) was used to increase the solubility of turmeric rhizome oleoresin (TRO) in aqueous solution by forming inclusion complexes, and the technique was combined with microwave-assisted extraction (MAE) to extract the curcuminoids from Curcuma domestica Val. Optimized conditions for the MAE were microwave power of 700 W, extraction particle size of 0.30–0.60 mm, extraction time of 3 min, solvent volume of 10 mL, 2 g of sample, and extraction temperature of 60 °C. High-performance liquid chromatography was used for the determination of the curcuminoids. Phase solubility study was conducted to investigate the association of Mβ-CD with TRO using curcumin, the major curcuminoid, as a marker compound to represent turmeric oleoresin. The curcumin recovery was increased due to its complexation with Mβ-CD. Linear host–guest correlation with slope of <1 indicated a stoichiometry of 1:1 Mβ-CD-complex, and with this assumption, the stability constant, K C , was calculated as 515.19 M−1. Meanwhile, the molar ratio needed for inclusion complexation between TRO/Mβ-CD was 1:2. Attenuated total reflectance Fourier transform infrared spectroscopy results revealed that the MAE application for the co-precipitation, physical, and kneading methods can all be used for complexation.

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Acknowledgments

The authors thank Universiti Teknologi Malaysia and the Ministry of Education, Malaysia (MOE), for facilitations and financial support through Grant No. [Q.J130000.2526.03H79].

Conflict of Interest

Binta Jume Hadi declares no conflict interest. Mohd Marsin Sanag declares no conflict interest. Hassan Y. Aboul-Enein declares no conflict interest. Wan Aini Wan Ibrahim declares no conflict interest. Shajarahtunnur Jamil declares no conflict interest. Mohammed Abdullahi Mu’az declares no conflict interest. The authors declare that this study does not involve human or animals.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Science, Universiti Teknologi Malaysia, 81310, Johor Bahru, Johor, Malaysia

    Binta Jume Hadi, Mohd Marsin Sanagi, Wan Aini Wan Ibrahim & Shajarahtunnur Jamil

  2. Ibnu Sina Institute for Fundamental Science Studies, Nanotechnology Research Alliance, Universiti Teknologi Malaysia, 81310, Johor Bahru, Johor, Malaysia

    Mohd Marsin Sanagi

  3. Pharmaceutical and Drug Industries Research Division, Department of Pharmaceutical and Medicinal Chemistry, National Research Centre, Dokki, Cairo, 12311, Egypt

    Hassan Y. Aboul-Enein

  4. Department of Civil Engineering, Jubail University College, Jubail Industrial City, 31961, Kingdom of Saudi Arabia

    Mohammed Abdullahi Mu’azu

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  1. Binta Jume Hadi
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  2. Mohd Marsin Sanagi
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  3. Hassan Y. Aboul-Enein
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  4. Wan Aini Wan Ibrahim
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  5. Shajarahtunnur Jamil
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  6. Mohammed Abdullahi Mu’azu
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Correspondence to Mohd Marsin Sanagi or Hassan Y. Aboul-Enein.

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Hadi, B.J., Sanagi, M.M., Aboul-Enein, H.Y. et al. Microwave-Assisted Extraction of Methyl β-Cyclodextrin-Complexed Curcumin from Turmeric Rhizome Oleoresin. Food Anal. Methods 8, 2447–2456 (2015). https://doi.org/10.1007/s12161-015-0137-3

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