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Signaling network of Oncostatin M pathway

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Fig. 1

Abbreviations

AKT:

v-akt murine thymoma viral oncogene homolog 1

JAK:

Janus kinase

LIFR:

Leukemia inhibiting factor

MAPK:

Mitogen-activated protein kinase

OSM:

Oncostatin M

OSMR-beta:

OSM receptor-beta subunit

PI3K:

Phosphoinositide 3-kinase

PTMs:

Post-translational modifications

STAT:

Signal transduction and activator of transcription

References

  • Albasanz-Puig A, Murray J, Namekata M, Wijelath ES (2012) Opposing roles of STAT-1 and STAT-3 in regulating vascular endothelial growth factor expression in vascular smooth muscle cells. Biochem Biophys Res Commun 428(1):179–184

    Article  PubMed  CAS  Google Scholar 

  • Arita K, South AP, Hans-Filho G, Sakuma TH, Lai-Cheong J, Clements S, Odashiro M, Odashiro DN, Hans-Neto G, Hans NR et al (2008) Oncostatin M receptor-beta mutations underlie familial primary localized cutaneous amyloidosis. Am J Hum Genet 82:73–80

    Article  PubMed  CAS  Google Scholar 

  • Blanchard F, Wang Y, Kinzie E, Duplomb L, Godard A, Baumann H (2001) Oncostatin M regulates the synthesis and turnover of gp130, leukemia inhibitory factor receptor alpha, and oncostatin M receptor beta by distinct mechanisms. J Biol Chem 276:47038–47045

    Article  PubMed  CAS  Google Scholar 

  • Boeckmann B, Bairoch A, Apweiler R, Blatter MC, Estreicher A, Gasteiger E, Martin MJ, Michoud K, O’Donovan C, Phan I, Pilbout S, Schneider M (2003) The SWISS-PROT protein knowledgebase and its supplement TrEMBL in 2003. Nucleic Acids Res 31:365–370

    Article  PubMed  CAS  Google Scholar 

  • Cao A, Wu M, Li H, Liu J (2011) Janus kinase activation by cytokine oncostatin M decreases PCSK9 expression in liver cells. J Lipid Res 52:518–530

    Article  PubMed  CAS  Google Scholar 

  • Douglas AM, Goss GA, Sutherland RL, Hilton DJ, Berndt MC, Nicola NA, Begley CG (1997) Expression and function of members of the cytokine receptor superfamily on breast cancer cells. Oncogene 14:661–669

    Article  PubMed  CAS  Google Scholar 

  • Douglas AM, Grant SL, Goss GA, Clouston DR, Sutherland RL, Begley CG (1998) Oncostatin M induces the differentiation of breast cancer cells. Int J Cancer 75:64–73

    Article  PubMed  CAS  Google Scholar 

  • Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R et al (1999) The DNA sequence of human chromosome 22. Nature 402:489–495

    Article  PubMed  CAS  Google Scholar 

  • Ensoli F, Fiorelli V, DeCristofaro M, Santini Muratori D, Novi A, Vannelli B, Thiele CJ, Luzi G, Aiuti F (1999) Inflammatory cytokines and HIV-1-associated neurodegeneration: oncostatin-M produced by mononuclear cells from HIV-1-infected individuals induces apoptosis of primary neurons. J Immunol 162:6268–6277

    PubMed  CAS  Google Scholar 

  • Fossey SL, Bear MD, Kisseberth WC, Pennell M, London CA (2011) Oncostatin M promotes STAT3 activation, VEGF production, and invasion in osteosarcoma cell lines. BMC Cancer 11:125

    Article  PubMed  CAS  Google Scholar 

  • Goel R, Harsha HC, Pandey A, Prasad TSK (2012) Human protein reference database and human proteinpedia as resources for phosphoproteome analysis. Mol Biosyst 8:453–463

    Article  PubMed  CAS  Google Scholar 

  • Goel R, Raju R, Maharudraiah J, Kumar GSS, Ghosh K, Kumar A, Lashmi PT et al (2011) A signaling network of thyroid-stimulating hormone. J Proteome Bioinforma 4:238–241

    CAS  Google Scholar 

  • Hamosh A, Scott AF, Amberger JS, Bocchini CA, McKusick VA (2005) Online Mendelian Inheritance in Man (OMIM), a knowledgebase of human genes and genetic disorders. Nucleic Acids Res 33:D514–D517

    Article  PubMed  CAS  Google Scholar 

  • Hasegawa M, Sato S, Ihn H, Takehara K (1999) Enhanced production of interleukin-6 (IL-6), oncostatin M and soluble IL-6 receptor by cultured peripheral blood mononuclear cells from patients with systemic sclerosis. Rheumatology (Oxford) 38:612–617

    Article  CAS  Google Scholar 

  • Heinrich PC, Behrmann I, Haan S, Hermanns HM, Muller-Newen G, Schaper F (2003) Principles of interleukin (IL)-6-type cytokine signalling and its regulation. Biochem J 374:1–20

    Article  PubMed  CAS  Google Scholar 

  • Hoffman RC, Moy FJ, Price V, Richardson J, Kaubisch D, Frieden EA, Krakover JD, Castner BJ, King J, March CJ, Powers R (1996) Resonance assignments for oncostatin M, a 24-kDa alpha-helical protein. J Biomol NMR 7:273–282

    Article  PubMed  CAS  Google Scholar 

  • Kandasamy K, Keerthikumar S, Raju R, Prasad TSK, Ramachandra YL, Mohan S, Pandey A (2009) PathBuilder–open source software for annotating and developing pathway resources. Bioinformatics 25:2860–2862

    Article  PubMed  CAS  Google Scholar 

  • Kandasamy K, Mohan SS, Raju R, Keerthikumar S, Kumar GS, Venugopal AK, Telikicherla D et al (2010) NetPath: a public resource of curated signal transduction pathways. Genome Biol 11:R3

    Article  PubMed  Google Scholar 

  • Kok SH, Hou KL, Hong CY, Wang JS, Liang PC, Chang CC, Hsiao M, Yang H, Lai EH, Lin SK (2011) Simvastatin inhibits cytokine-stimulated Cyr61 expression in osteoblastic cells: a therapeutic benefit for arthritis. Arthritis Rheum 63:1010–1020

    Article  PubMed  CAS  Google Scholar 

  • Li Q, Zhu J, Sun F, Liu L, Liu X, Yue Y (2011) Oncostatin M promotes proliferation of ovarian cancer cells through signal transducer and activator of transcription 3. Int J Mol Med 28:101–108

    PubMed  CAS  Google Scholar 

  • Linsley PS, Kallestad J, Ochs V, Neubauer M (1990) Cleavage of a hydrophilic C-terminal domain increases growth-inhibitory activity of oncostatin M. Mol Cell Biol 10:1882–1890

    PubMed  CAS  Google Scholar 

  • Maglott D, Ostell J, Pruitt KD, Tatusova T (2005) Entrez Gene: gene-centered information at NCBI. Nucleic Acids Res 33:D54–D58

    Article  PubMed  CAS  Google Scholar 

  • Migita K, Komori A, Torigoshi T, Maeda Y, Izumi Y, Jiuchi Y, Miyashita T, Nakamura M, Motokawa S, Ishibashi H (2011) CP690,550 inhibits oncostatin M-induced JAK/STAT signaling pathway in rheumatoid synoviocytes. Arthritis Res Ther 13:R72

    Article  PubMed  CAS  Google Scholar 

  • Nanjappa V, Raju R, Muthusamy B, Sharma J, Thomas K, Nidhina PAH, Harsha HC, Pandey A, Anilkumar G, Prasad TSK (2011) A comprehensive curated reaction map of leptin signaling pathway. J Proteome Bioinforma 4:184–189

    Google Scholar 

  • Nicolaidou V, Wong MM, Redpath AN, Ersek A, Baban DF, Williams LM, Cope AP, Horwood NJ (2012) Monocytes induce STAT3 activation in human mesenchymal stem cells to promote osteoblast formation. PLoS One 7:e39871

    Article  PubMed  CAS  Google Scholar 

  • O’Hara KA, Kedda MA, Thompson PJ, Knight DA (2003) Oncostatin M: an interleukin-6-like cytokine relevant to airway remodelling and the pathogenesis of asthma. Clin exp allergy: j Br Soc Allergy Clin Immunol 33:1026–1032

    Article  Google Scholar 

  • Prasad TSK, Kandasamy K, Pandey A (2009) Human protein reference database and human proteinpedia as discovery tools for systems biology. Methods Mol Biol 577:67–79

    Article  PubMed  CAS  Google Scholar 

  • Raju R, Balakrishnan L, Nanjappa V, Bhattacharjee M, Getnet D, Muthusamy B, Kurian Thomas J et al. (2011a) A comprehensive manually curated reaction map of RANKL/RANK-signaling pathway. Database (Oxford) 2011: bar021

  • Raju R, Nanjappa V, Balakrishnan L, Radhakrishnan A, Thomas JK, Sharma J, Tian M, Palapetta SM, Subbannayya T et al. (2011b) NetSlim:high-confidence curated signaling maps. Database (Oxford) 2011:bar032

  • Ruprecht K, Kuhlmann T, Seif F, Hummel V, Kruse N, Bruck W, Rieckmann P (2001) Effects of oncostatin M on human cerebral endothelial cells and expression in inflammatory brain lesions. J Neuropathol Exp Neurol 60:1087–1098

    PubMed  CAS  Google Scholar 

  • Sarkozi R, Hauser C, Noppert SJ, Kronbichler A, Pirklbauer M, Haller VM, Grillari J, Grillari-Voglauer R, Mayer G, Schramek H (2011) Oncostatin M is a novel inhibitor of TGF-beta1-induced matricellular protein expression. Am J Physiol Renal Physiol 301:F1014–F1025

    Article  PubMed  Google Scholar 

  • Schaefer LK, Wang S, Schaefer TS (2000) Oncostatin M activates stat DNA binding and transcriptional activity in primary human fetal astrocytes: low- and high-passage cells have distinct patterns of stat activation. Cytokine 12:1647–1655

    Article  PubMed  CAS  Google Scholar 

  • Taga T, Kishimoto T (1997) Gp130 and the interleukin-6 family of cytokines. Annu Rev Immunol 15:797–819

    Article  PubMed  CAS  Google Scholar 

  • Tanaka M, Miyajima A (2003) Oncostatin M, a multifunctional cytokine. Rev Physiol Biochem Pharmacol 149:39–52

    Article  PubMed  CAS  Google Scholar 

  • Thoma B, Bird TA, Friend DJ, Gearing DP, Dower SK (1994) Oncostatin M and leukemia inhibitory factor trigger overlapping and different signals through partially shared receptor complexes. J Biol Chem 269:6215–6222

    PubMed  CAS  Google Scholar 

  • Tu HJ, Lin TH, Chiu YC, Tang CH, Yang RS, Fu WM (2012) Enhancement of placenta growth factor expression by oncostatin M in human rheumatoid arthritis synovial fibroblasts. J Cell Physiol

  • Van Wagoner NJ, Choi C, Repovic P, Benveniste EN (2000) Oncostatin M regulation of interleukin-6 expression in astrocytes: biphasic regulation involving the mitogen-activated protein kinases ERK1/2 and p38. J Neurochem 75:563–575

    Article  PubMed  Google Scholar 

  • Weiss TW, Kvakan H, Kaun C, Zorn G, Speidl WS, Pfaffenberger S, Maurer G, Huber K, Wojta J (2005) The gp130 ligand oncostatin M regulates tissue inhibitor of metalloproteinases-1 through ERK1/2 and p38 in human adult cardiac myocytes and in human adult cardiac fibroblasts: a possible role for the gp130/gp130 ligand system in the modulation of extracellular matrix degradation in the human heart. J Mol Cell Cardiol 39:545–551

    Article  PubMed  CAS  Google Scholar 

  • Zarling JM, Shoyab M, Marquardt H, Hanson MB, Lioubin MN, Todaro GJ (1986) Oncostatin M: a growth regulator produced by differentiated histiocytic lymphoma cells. Proc Natl Acad Sci U S A 83:9739–9743

    Article  PubMed  CAS  Google Scholar 

  • Zhang F, Li C, Halfter H, Liu J (2003) Delineating an oncostatin M-activated STAT3 signaling pathway that coordinates the expression of genes involved in cell cycle regulation and extracellular matrix deposition of MCF-7 cells. Oncogene 22:894–905

    Article  PubMed  CAS  Google Scholar 

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Acknowledgments

We thank the Department of Biotechnology, Government of India for research support to the Institute of Bioinformatics, Bangalore. Gourav Dey and Nazia Syed are recipients of Junior Research Fellowship from the University Grants Commission (UGC), Government of India. Aneesha Radhakrishnan is a recipient of a Senior Research Fellowship from the Council of Scientific and Industrial Research (CSIR), Government of India. We thank G. S Sameer Kumar and Renu Goel for assistance in curation.

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The author(s) declared no conflicts of interests.

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Correspondence to T. S. Keshava Prasad.

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Gourav Dey and Aneesha Radhakrishnan contributed equally.

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Dey, G., Radhakrishnan, A., Syed, N. et al. Signaling network of Oncostatin M pathway. J. Cell Commun. Signal. 7, 103–108 (2013). https://doi.org/10.1007/s12079-012-0186-y

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