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Onconstatin M, a multifunctional cytokine

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Reviews of Physiology, Biochemistry and Pharmacology

Part of the book series: Reviews of Physiology, Biochemistry and Pharmacology ((REVIEWS,volume 149))

Abstract

Oncostatin M (OSM) is a multifunctional cytokine that belongs to the Interleukin (IL)-6 subfamily. Among the family members, OSM is most closely related to leukemia inhibitory factor (LIF) and it in fact utilizes the LIF receptor in addition to its specific receptor in the human. While OSM was originally recognized by its unique activity to inhibit the proliferation of tumor cells, accumulating evidence now indicates that OSM exhibits many unique biological activities in inflammation, hematopoiesis, and development. Here, we review the profile of OSM activities, receptors, and signal transduction.

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Abbreviations

G-CSF:

Granulocyte-colony stimulating factor

GM-CSF:

Granulocyte-macrophage colony stimulating factor

GAS:

γ Interferon-activated site

Grb:

Growth factor receptor-bound protein

Gab:

Grb-2-associated binder

SHP:

SH2 domain-containing protein tyrosine phosphatase

STAT:

Signal transducer and activator of transcription

TEL:

Translocated ets leukemia

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Authors and Affiliations

  1. Institue of Molelcular and Cellular Biosciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, 113-0032, Tokyo, Japan

    M. Tanaka & A. Miyahima

  2. Kanagawa Academy of Science and Technology, Osaka University, 907 Nogawa, Miyamae-ku, 216-001, Kawasaki, Japan

    M. Tanaka & A. Miyahima

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  1. M. Tanaka
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  2. A. Miyahima
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Correspondence to M. Tanaka .

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© 2003 Springer-Verlag

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Tanaka, M., Miyahima, A. (2003). Onconstatin M, a multifunctional cytokine. In: Reviews of Physiology, Biochemistry and Pharmacology. Reviews of Physiology, Biochemistry and Pharmacology, vol 149. Springer, Berlin, Heidelberg. https://doi.org/10.1007/s10254-003-0013-1

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  • DOI: https://doi.org/10.1007/s10254-003-0013-1

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  • Print ISBN: 978-3-540-20213-4

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