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Delayed Ejaculation: Medical and Psychological Treatments and Algorithm

  • Male Sexual Dysfunction and Disorders (SE Althof and AW Pastuszak, Section Editors)
  • Published:
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Abstract

Delayed ejaculation (DE) is a challenging disorder to treat. Many clinicians are not comfortable dealing with DE due to a lack of treatment approaches supported by evidence-based medicine. In this review, we discuss the most common treatments and the latest studies that support each DE treatment. The goal of our review is to help clinicians identify and treat patients who present with this disorder. An integrative approach using medications, penile vibratory stimulation, and sexual counseling is important for successful treatment of DE. We propose an algorithm for DE treatment to help guide clinicians. However, an individualized treatment plan should be developed for each unique case due to the multifactorial etiology of DE.

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References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

  1. Bronner G, Ben-Zion IZ. Unusual masturbatory practice as an etiological factor in the diagnosis and treatment of sexual dysfunction in young men. J Sex Med. 2014;11(7):1798–806. This was an interesting approach to obtaining sexual histories around masturbation and idiopathic styles.

    Article  PubMed  Google Scholar 

  2. Mulhall JP, Hsiao W. Chapter 9—delayed ejaculation and orgasm. In: Nelson CJ, Brock D, Dean RC, editors. Men’s sexual health and fertility: a clinician’s guide. New York: Springer; 2014. p. 145–58. The chapter on delayed ejaculation was a good review of the literature and outlined treatments.

    Chapter  Google Scholar 

  3. Rowland D, McMahon CG, Abdo C, Chen J, Jannini E, Waldinger MD, et al. Disorders of orgasm and ejaculation in men. J Sex Med. 2010;7(4 Pt 2):1668–86.

  4. Aukst-Margetic B, Margetic B. An open-label series using loratadine for the treatment of sexual dysfunction associated with selective serotonin reuptake inhibitors. Prog Neuropsychopharmacol Biol Psychiatry. 2005;29(5):754–6.

    Article  CAS  PubMed  Google Scholar 

  5. Shin D, Spitz A. The evaluation and treatment of delayed ejaculation. Sex Med Rev. 2014;2(3–4):121–33. This is another excellent review of the topic of DE and the treatments.

    Article  Google Scholar 

  6. Yager J. Bethanechol chloride can reverse erectile and ejaculatory dysfunction induced by tricyclic antidepressants and mazindol: case report. J Clin Psychiatry. 1986;47(4):210–1.

    CAS  PubMed  Google Scholar 

  7. Lue TF, Basson R, Rosen R, Guiliano F, Khoury S, Montorsi F. Sexual medicine: sexual dysfunctions in men and women. Plymouth: Health Publications; 2004.

  8. Association, A.P. Diagnostic and statistical manual of mental disorders. Fifthth ed. Washington: American Psychiatric Publishing; 2013. p. 423–9.

    Google Scholar 

  9. Patrick DL, Althof SE, Pryor JL, Rosen R, Rowland DL, Ho KF, et al. Premature ejaculation: an observational study of men and their partners. J Sex Med. 2005;2(3):358–67.

  10. Waldinger MD, Quinn P, Dilleen M, Mundayat R, Schweitzer DH, Boolell M. A multinational population survey of intravaginal ejaculation latency time. J Sex Med. 2005;2(4):492–7.

  11. Rowland DL, Keeney C, Slob AK. Sexual response in men with inhibited or retarded ejaculation. Int J Impot Res. 2004;16(3):270–4.

    Article  CAS  PubMed  Google Scholar 

  12. Nathan SG. The epidemiology of the DSM-III psychosexual dysfunctions. J Sex Marital Ther. 1986;12(4):267–81.

    Article  CAS  PubMed  Google Scholar 

  13. Richardson D, Nalabanda A, Goldmeier D. Retarded ejaculation—a review. Int J STD AIDS. 2006;17(3):143–50.

    Article  PubMed  Google Scholar 

  14. Spector IP, Carey MP. Incidence and prevalence of the sexual dysfunctions: a critical review of the empirical literature. Arch Sex Behav. 1990;19(4):389–408.

    Article  CAS  PubMed  Google Scholar 

  15. Georgiadis JR, Reinders AA, Van der Graaf FH, Paans AM, Kortekaas R. Brain activation during human male ejaculation revisited. Neuroreport. 2007;18(6):553–7.

  16. Porst H, Buvat J, Standards Committee of the International Society for Sexual Medicine, editors. Standard practice in sexual medicine. Malden, Mass.; Oxford: Blackwell Pub.; 2006.

  17. McMahon CG, Abdo C, Incrocci L, Perelman M, Rowland D, Waldinger M, et al. Disorders of orgasm and ejaculation in men. J Sex Med. 2004;1(1):58–65.

  18. Butcher M, et al. Delayed ejaculation remains a recalcitrant condition: results of a SMSNA survey. 20th Annual Fall Scientific Meeting of SMSNA, November 20–23, 2014 Program Book, 2014(Abstract 041): p. 70.

  19. Perelman MA. A new combination treatment for premature ejaculation: a sex therapist’s perspective. J Sex Med. 2006;3(6):1004–12.

    Article  PubMed  Google Scholar 

  20. Binik YM, Hall KSK. Chapter 6: delayed ejaculation. In: Perelman MA, editor. Principles and practice of sex therapy. Fifthth ed. New York: The Guilford Press; 2014. p. 138–55. The chapter reviewed sexual dysfunction and included DE which was very helpful.

    Google Scholar 

  21. Waldinger MD. Toward evidence-based genetic research on lifelong premature ejaculation: a critical evaluation of methodology. Korean J Urol. 2011;52(1):1–8.

    Article  PubMed Central  PubMed  Google Scholar 

  22. Gregoire A. ABC of sexual health: assessing and managing male sexual problems. BMJ. 1999;318(7179):315–7.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  23. Minderhoud JM, Leemhuis JG, Kremer J, Laban E, Smits PM. Sexual disturbances arising from multiple sclerosis. Acta Neurol Scand. 1984;70(4):299–306.

  24. Jannini EA, Simonelli C, Lenzi A. Disorders of ejaculation. J Endocrinol Invest. 2002;25(11):1006–19.

    Article  CAS  PubMed  Google Scholar 

  25. Corona G, Ricca V, Bandini E, Mannucci E, Lotti F, Boddi V, et al. Selective serotonin reuptake inhibitor-induced sexual dysfunction. J Sex Med. 2009;6(5):1259–69.

  26. Kiev A, Feiger A. A double-blind comparison of fluvoxamine and paroxetine in the treatment of depressed outpatients. J Clin Psychiatry. 1997;58(4):146–52.

    Article  CAS  PubMed  Google Scholar 

  27. Althof SE. Psychological interventions for delayed ejaculation/orgasm. Int J Impot Res. 2012;24(4):131–6.

    Article  CAS  PubMed  Google Scholar 

  28. Perelman M. Idiosyncratic masturbation patterns: a key unexplored variable in the treatment of retarded ejaculation by the practicing urologist. J Urol. 2005;173:340. Abstract 1254.

    Article  Google Scholar 

  29. Teloken P, Nelson C, Mullhall J. Outcomes with medical treatment of secondary delayed orgasm proposal of a clinical care pathway. Journal of Urology. 2012;187(4, Supplement 1496):e606.

    Article  Google Scholar 

  30. Butcher M, et al. How is delayed ejaculation defined and treated in North America? Andrology. 2015.

  31. McMahon CG, Jannini E, Waldinger M, Rowland D. Standard operating procedures in the disorders of orgasm and ejaculation. J Sex Med. 2013;10(1):204–29. This was an excellent review of the pathophysiology, etioloies and treatments for DE.

  32. McMahon CG. Management of ejaculatory dysfunction. Intern Med J. 2014;44(2):124–31.

    Article  CAS  PubMed  Google Scholar 

  33. Kendirci M, Hellstrom WJ. Intranasal apomorphine. IDrugs. 2004;7(5):483–8. Nastech Pharmaceutical.

    CAS  PubMed  Google Scholar 

  34. Taylor MJ. Strategies for managing antidepressant-induced sexual dysfunction: a review. Curr Psychiatry Rep. 2006;8(6):431–6.

    Article  PubMed  Google Scholar 

  35. Schweitzer I, Maguire K, Ng C. Sexual side-effects of contemporary antidepressants: review. Aust N Z J Psychiatry. 2009;43(9):795–808.

    Article  PubMed  Google Scholar 

  36. Kruger TH, Haake P, Haverkamp J, Krämer M, Exton MS, Saller B et al. Effects of acute prolactin manipulation on sexual drive and function in males. J Endocrinol. 2003;179(3):357–65.

  37. Wittstock M, Benecke R, Dressler D. Cabergoline can increase penile erections and libido. Neurology. 2002;58(5):831.

    Article  PubMed  Google Scholar 

  38. Kruger TH, Hartmann U, Schedlowski M. Prolactinergic and dopaminergic mechanisms underlying sexual arousal and orgasm in humans. World J Urol. 2005;23(2):130–8.

  39. DeBattista C, Solvason B, Poirier J, Kendrick E, Loraas E. A placebo-controlled, randomized, double-blind study of adjunctive bupropion sustained release in the treatment of SSRI-induced sexual dysfunction. J Clin Psychiatry. 2005;66(7):844–8.

  40. Labbate LA, Grimes JB, Hines A, Pollack MH. Bupropion treatment of serotonin reuptake antidepressant-associated sexual dysfunction. Ann Clin Psychiatry. 1997;9(4):241–5.

  41. Ashton AK, Rosen RC. Bupropion as an antidote for serotonin reuptake inhibitor-induced sexual dysfunction. J Clin Psychiatry. 1998;59(3):112–5.

  42. Clayton AH, Warnock JK, Kornstein SG, Pinkerton R, Sheldon-Keller A, McGarvey EL. A placebo-controlled trial of bupropion SR as an antidote for selective serotonin reuptake inhibitor-induced sexual dysfunction. J Clin Psychiatry. 2004;65(1):62–7.

  43. Safarinejad MR. Midodrine for the treatment of organic anejaculation but not spinal cord injury: a prospective randomized placebo-controlled double-blind clinical study. Int J Impot Res. 2009;21(4):213–20.

    Article  CAS  PubMed  Google Scholar 

  44. Veening JG, de Jong TR, Waldinger MD, Korte SM, Olivier B. The role of oxytocin in male and female reproductive behavior. Eur J Pharmacol. 2014;753:209–28.

  45. Corona G, Jannini EA, Vignozzi L, Rastrelli G, Maggi M. The hormonal control of ejaculation. Nat Rev Urol. 2012;9(9):508–19.

  46. Filippi S, Vannelli GB, Granchi S, Luconi M, Crescioli C, Mancina R et al. Identification, localization and functional activity of oxytocin receptors in epididymis. Mol Cell Endocrinol. 2002;193(1–2):89–100.

  47. Vignozzi L, Filippi S, Luconi M, Morelli A, Mancina R, Marini M, et al. Oxytocin receptor is expressed in the penis and mediates an estrogen-dependent smooth muscle contractility. Endocrinology. 2004;145(4):1823–34.

  48. Burri A, Heinrichs M, Schedlowski M, Kruger TH. The acute effects of intranasal oxytocin administration on endocrine and sexual function in males. Psychoneuroendocrinology. 2008;33(5):591–600.

  49. MacDonald K, Feifel D. Dramatic improvement in sexual function induced by intranasal oxytocin. J Sex Med. 2012;9(5):1407–10.

  50. Ishak WW, Berman DS, Peters A. Male anorgasmia treated with oxytocin. J Sex Med. 2008;5(4):1022–4.

  51. Ashton AK, Hamer R, Rosen RC. Serotonin reuptake inhibitor-induced sexual dysfunction and its treatment: a large-scale retrospective study of 596 psychiatric outpatients. J Sex Marital Ther. 1997;23(3):165–75.

    Article  Google Scholar 

  52. Lauerma H. Successful treatment of citalopram-induced anorgasmia by cyproheptadine. Acta Psychiatr Scand. 1996;93(1):69–70.

    Article  CAS  PubMed  Google Scholar 

  53. Steele TE, Howell EF. Cyproheptadine for imipramine-induced anorgasmia. J Clin Psychopharmacol. 1986;6(5):326–7.

    Article  CAS  PubMed  Google Scholar 

  54. Sovner R. Treatment of tricyclic antidepressant-induced orgasmic inhibition with cyproheptadine. J Clin Psychopharmacol. 1984;4(3):169.

    Article  CAS  PubMed  Google Scholar 

  55. McCormick S, Olin J, Brotman AW. Reversal of fluoxetine-induced anorgasmia by cyproheptadine in two patients. J Clin Psychiatry. 1990;51(9):383–4.

    CAS  PubMed  Google Scholar 

  56. Feder R. Reversal of antidepressant activity of fluoxetine by cyproheptadine in three patients. J Clin Psychiatry. 1991;52(4):163–4.

    CAS  PubMed  Google Scholar 

  57. Landen M, Eriksson E, Agren H, Fahlén T. Effect of buspirone on sexual dysfunction in depressed patients treated with selective serotonin reuptake inhibitors. J Clin Psychopharmacol. 1999;19(3):268–71.

  58. Othmer E, Othmer SC. Effect of buspirone on sexual dysfunction in patients with generalized anxiety disorder. J Clin Psychiatry. 1987;48(5):201–3.

  59. Carro-Juareza M, Rodriguez-Manzo G. Yohimbine reverses the exhaustion of the coital reflex in spinal male rats. Behav Brain Res. 2003;141(1):43–50.

  60. Ferraz MM, Fontanella JC, Damasceno F, Silva de Almeida OM, Ferraz MR. Chronic amantadine treatment enhances the sexual behaviour of male rats. Pharmacol Biochem Behav. 2007;86(4):616–21.

  61. Stafford SA, Coote JH. Activation of D2-like receptors induces sympathetic climactic-like responses in male and female anaesthetised rats. Br J Pharmacol. 2006;148(4):510–6.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  62. Lu W, Jiang W, Chen J, Yin M, Wang Z, Jiang X. Modulation of brain delivery and copulation by intranasal apomorphine hydrochloride. Int J Pharm. 2008;349(1–2):196–205.

  63. Segraves RT. Reversal by bethanechol of imipramine-induced ejaculatory dysfunction. Am J Psychiatry. 1987;144(9):1243–4.

    CAS  PubMed  Google Scholar 

  64. Melnyk J, Marcone M. Aphrodisiacs from plant and animal sources—a review of current scientific literature. Food Res Int. 2011;44:840–50.

  65. Haberfellner EM. Sexual dysfunction caused by reboxetine. Pharmacopsychiatry. 2002;35(2):77–8.

    Article  CAS  PubMed  Google Scholar 

  66. O’Flynn R, Michael A. Reboxetine-induced spontaneous ejaculation. Br J Psychiatry. 2000;177:567–8.

    Article  PubMed  Google Scholar 

  67. Sivrioglu EY, Topaloglu VC, Sarandol A, Akkaya C, Eker SS, Kirli S. Reboxetine induced erectile dysfunction and spontaneous ejaculation during defecation and micturition. Prog Neuropsychopharmacol Biol Psychiatry. 2007;31(2):548–50.

  68. Sonksen J, Ohl DA. Penile vibratory stimulation and electroejaculation in the treatment of ejaculatory dysfunction. Int J Androl. 2002;25(6):324–32.

    Article  PubMed  Google Scholar 

  69. Sonksen J, Ohl DA, Wedemeyer G. Sphincteric events during penile vibratory ejaculation and electroejaculation in men with spinal cord injuries. J Urol. 2001;165(2):426–9.

  70. Nelson CJ, Ahmed A, Valenzuela R, Parker M, Mulhall JP. Assessment of penile vibratory stimulation as a management strategy in men with secondary retarded orgasm. Urology. 2007;69(3):552–5. discussion 555–6.

  71. Gerig NE, Meacham RB, Ohl DA. Use of electroejaculation in the treatment of ejaculatory failure secondary to diabetes mellitus. Urology. 1997;49(2):239–42.

    Article  CAS  PubMed  Google Scholar 

  72. Prévinaire JG, Lecourt G, Soler JM, Denys P. Sexual disorders in men with multiple sclerosis: evaluation and management. Ann Phys Rehabil Med. 2014;57(5):329–36.

  73. Fode M, Borre M, Ohl DA, Lichtbach J, Sønksen J. Penile vibratory stimulation in the recovery of urinary continence and erectile function after nerve-sparing radical prostatectomy: a randomized, controlled trial. BJU Int. 2014;114(1):111–7. Demonstration of PVS for ED and neurologic causes of DE are described herein.

  74. Fode M, Sonksen J. Penile vibratory stimulation in the treatment of post-prostatectomy incontinence: a randomized pilot study. Neurourol Urodyn. 2015;34(2):117–22.

  75. Lieblum S, Rosen R. Principles and practice of sex therapy. 2nd ed. New York: Guilford Press; 2000.

  76. Rowland D, van Diest S, Incrocci L, Slob AK. Psychosexual factors that differentiate men with inhibited ejaculation from men with no dysfunction or another sexual dysfunction. J Sex Med. 2005;2(3):383–9.

  77. McCarthy BW. Strategies and techniques for the treatment of inhibited sexual desire. J Sex Marital Ther. 1984;10(2):97–104.

    Article  CAS  PubMed  Google Scholar 

  78. Perelman MA, Rowland DL. Retarded ejaculation. World J Urol. 2006;24(6):645–52.

  79. Carvalheira A, Traeen B, Stulhofer A. Masturbation and pornography use among coupled heterosexual men with decreased sexual desire: how many roles of masturbation? J Sex Marital Ther. 2014: p. 1–10. Pornography and masturbation can lead to dissociation for men during partnered sex.

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Conflict of Interest

Daniel J. Sadowski and Michael J. Butcher declare no conflicts of interest.

Tobias S. Köhler declares the receipt of grants and personal fees from AMS and Coloplast and personal fees from Auxilium, outside the submitted work.

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This article does not contain any studies with human or animal subjects performed by any of the authors.

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Correspondence to Michael J. Butcher.

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This article is part of the Topical Collection on Male Sexual Dysfunction and Disorders

Appendices

Appendix 1: Treatment Algorithm for Ejaculatory Disorders

ψ = See collaboration of clinician and sexual therapist (Appendix 2).

* = Medications in Table 1 can be tried in treatment of retrograde ejaculation (see Table 1).

^ = If patient on SSRI consider use of SSRI antidote types of medications (see Table 1).

= Medications in Table 1 can be used for prolactin abnormalities (see Table 1).

Graphic based off of Rowland et al. Please see [3].

Appendix 2: Clinician and Sexual Therapist Integrative Therapy for Delayed Ejaculation

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Sadowski, D.J., Butcher, M.J. & Köhler, T.S. Delayed Ejaculation: Medical and Psychological Treatments and Algorithm. Curr Sex Health Rep 7, 170–179 (2015). https://doi.org/10.1007/s11930-015-0054-x

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