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Progressive External Ophthalmoplegia

  • Neuro-Ophthalmology (A Kawasaki, Section Editor)
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Abstract

Progressive external ophthalmoplegia (PEO), marked by progressive bilateral ptosis and diffuse reduction in ocular motility, represents a finding of mitochondrial myopathy rather than a true diagnosis. PEO often occurs with other systemic features of mitochondrial dysfunction that can cause significant morbidity and mortality. Accurate and early recognition of PEO is paramount for the optimal care of these patients. We present an evidence-based review of the presenting neuro-ophthalmic features, differential diagnosis, diagnostic tools, systemic implications, and treatment options for isolated PEO and other PEO-associated mitochondrial syndromes.

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Acknowledgments

This research was supported by the unrestricted grant from the Research to Prevent Blindness (New York, NY).

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Authors and Affiliations

  1. Departments of Ophthalmology and Visual Neurosciences, University of Minnesota, 420 Delaware St. SE/MMC 493, Minneapolis, MN, 55455, USA

    Collin McClelland & Michael S. Lee

  2. Departments of Neurology, University of Minnesota, Minneapolis, MN, USA

    Georgios Manousakis & Michael S. Lee

  3. Departments of Neurosurgery, University of Minnesota, Minneapolis, MN, USA

    Michael S. Lee

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  1. Collin McClelland
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  2. Georgios Manousakis
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Correspondence to Michael S. Lee.

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Georgios Manousakis declares that he has no conflict of interest.

Collin McClelland is a consultant for an ophthalmology board review website (www.ophthoquestions.com) and has received an unrestricted grant from Research to Prevent Blindness.

Michael S. Lee has received grants from Eli Lilly, Pfizer, the National Eye Institute, Research to Prevent Blindness, and Quark Pharmaceuticals. Dr. Lee is also the founder and patent holder of Neuro-Ophthalmix.

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McClelland, C., Manousakis, G. & Lee, M.S. Progressive External Ophthalmoplegia. Curr Neurol Neurosci Rep 16, 53 (2016). https://doi.org/10.1007/s11910-016-0652-7

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