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Fibroblast Growth Factor Signaling in the Vasculature

  • Vascular Biology (T Hla, Section Editor)
  • Published:
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Abstract

Despite their discovery as angiogenic factors and mitogens for endothelial cells more than 30 years ago, much remains to be determined about the role of fibroblast growth factors (FGFs) and their receptors in vascular development, homeostasis, and disease. In vitro studies show that members of the FGF family stimulate growth, migration, and sprouting of endothelial cells, and growth, migration, and phenotypic plasticity of vascular smooth muscle cells. Recent studies have revealed important roles for FGFs and their receptors in the regulation of endothelial cell sprouting and vascular homeostasis in vivo. Furthermore, recent work has revealed roles for FGFs in atherosclerosis, vascular calcification, and vascular dysfunction. The large number of FGFs and their receptors expressed in endothelial and vascular smooth muscle cells complicates these studies. In this review, we summarize recent studies in which new and unanticipated roles for FGFs and their receptors in the vasculature have been revealed.

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Acknowledgments

The authors apologize to our many colleagues whose work could not be cited here due to space limitations. This work was supported in part by grants NIH P30 GM103392 (to RF), R01 HL109652 (to LL), AHA GRNT20460045 (to CV), R01 DK078161 (to LO). We also acknowledge the generous support of Maine Medical Center Research Institute.

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The authors declare that they have no conflict of interest.

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This article does contain any studies with human or animal subjects performed by any of the authors.

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Authors and Affiliations

  1. Center for Molecular Medicine, Maine Medical Center Research Institute, 81 Research Drive, Scarborough, ME, 04074, USA

    Xuehui Yang, Lucy Liaw, Igor Prudovsky, Peter C. Brooks, Calvin Vary, Leif Oxburgh & Robert Friesel

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  1. Xuehui Yang
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  2. Lucy Liaw
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  3. Igor Prudovsky
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  4. Peter C. Brooks
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  5. Calvin Vary
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  6. Leif Oxburgh
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  7. Robert Friesel
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Corresponding author

Correspondence to Robert Friesel.

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This article is part of the Topical Collection on Vascular Biology

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Yang, X., Liaw, L., Prudovsky, I. et al. Fibroblast Growth Factor Signaling in the Vasculature. Curr Atheroscler Rep 17, 31 (2015). https://doi.org/10.1007/s11883-015-0509-6

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  • DOI: https://doi.org/10.1007/s11883-015-0509-6

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