Abstract
In this study, the porous silk fibroin film (PSFF) is implanted into the body of a rat. Ten days later, the growing state of the capillaries in the material was observed, and the growing law of the capillaries in porous material is discussed to better understand the growing state of the peripheral tissue and cells around the material. The fact that the PSFF creates a beneficial environment for the growth of the capillaries in the tissue is confirmed, and the good growing states of the new skeleton muscle and the hypodermal tissue are also observed. This provides basic experimental results for the design of the PSFFs, which is a new medical biomaterial.
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Li M Z, Tao W, Kuga S, et al. Controlling molecular conformation of regenerated wild silk fibroin by aqueous ethanol treatment. Polymers for Advanced Technologies, 2003, 14(10): 694–698
Luan X Y, Zhang X G. Progress in immunological properties and cellular compatibility of silk fibroin research. International Journal of Biomedical Engineering, 2006, 29(5): 296–299 (in Chinese)
Zhou Y Z, Zhang S M, Li MZ, et al. The research of biocompatibility of bone marrow stem cells on silk fibroin flints. Chinese Journal of Neurosurgery, 2006, 22(10): 633–635 (in Chinese)
Huang B G, Zhu D A, Wu Z Y, et al. A new burn wound covering-fibroin membrane. Chinese Journal of Plastic Surgery and Burns, 1998, 7(14): 270–274 (in Chinese)
Bai L, Xu J M, Sun Q L, et al. Research on the growth density of the capillaries and the configuration of the porous silk fibroin film. Key Engineering Materials, 2007, 342–343: 229–232
Cheng L Z, Zhong C P, Cai W Q. Contemporary Histology. Shanghai: Shanghai Science and Technology Literature Publishing House, 2003, 681 (in Chinese)
Segal S S. Regulation of blood flow in the microcirculation. Microcirculation, 2005, 12: 33–45
Bloch E H, Iberall A S. Toward a concept of the functional unit of mammalian skeletal muscle. The American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, 1982, 242(5): R411–R420
Cossu G, Cicinilli P, Fieri C, et al. Emergence of TPA-resistant ’satellite’ cells during muscle histogenesis of human limb. Experimental Cell Research, 1985, 160(2): 403–411
Yablonka-Reuveni Z, Nameroff M. Skeletal muscle cell populations separation and partial characterization of fibroblast like cells from embryonic tissue using density centrifugation. Histochemistry, 1987, 87: 27–38
Weintraub H, Davis R, Tapscott S, et al. The myoD gene family: nodal point during specification of the muscle cell lineage. Science, 1991, 251: 761–766
Kitzmann M, Carnac G, Vandromme M, et al. The muscle regulatory factors MyoD and Myf-5 undergo distinct cell cycle-specific expression in muscle cell. The Journal of Cell Biology, 1998, 142(6): 1447–1459
Sabourin L A, Girgis-Gabardo A, Seale P, et al. Reduced differentiation potential of primary MyoD-1-myogenic cell derived from adult skeletal muscle. The Journal of Cell Biology, 1999, 144(4): 631–643
Skalli O, Schurch W, Seemayer T, et al. Myofibroblasts from diverse pathologic setting are hetero-geneous in their content of actin isoforms and intermediate filament proteins. Laboratory Investigation, 1989, 60: 275–285
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Bai, L., Zuo, Bq., Guan, Gp. et al. On the growth morphous of capillaries and tissue in porous silk fibroin films. Front. Mater. Sci. China 2, 266–270 (2008). https://doi.org/10.1007/s11706-008-0055-z
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DOI: https://doi.org/10.1007/s11706-008-0055-z