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Single-Anastomosis Gastric Bypass (SAGB): Appraisal of Clinical Evidence

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Abstract

Single-anastomosis (mini-) gastric bypass (SAGB) was proposed by Dr. Robert Rutledge. Criticism and prejudice against this procedure was raised by surgeons who preferred a more difficult procedure, laparoscopic Roux-en-Y gastric bypass (RYGB). Increasing data indicates the procedure is an effective and durable bariatric procedure. SAGB has lower operation risks compared to RYGB. The weight loss is better after SAGB because of a greater malabsorptive component than RYGB, but SAGB had a higher incidence of micronutrient deficiencies. Randomized controlled trial and long-term data demonstrate that SAGB can be regarded as a simpler and safer alternative to RYGB. We propose this procedure to be renamed “single-anastomosis gastric bypass (SAGB)” because the key feature of SAGB is the “single anastomosis” compared with the two anastomoses of RYGB.

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References

  1. Flegal KM, Carroll MD, Kit BK, et al. Prevalence of obesity and trends in the distribution of body mass index among US adults, 1999–2010. JAMA J Am Med Assoc. 2012;307(5):491–7. doi:10.1001/jama.2012.39.

    Article  Google Scholar 

  2. Kopelman PG. Obesity as a medical problem. Nature. 2000;404(6778):635–43. doi:10.1038/35007508.

    CAS  PubMed  Google Scholar 

  3. Prospective Studies C, Whitlock G, Lewington S, et al. Body-mass index and cause-specific mortality in 900 000 adults: collaborative analyses of 57 prospective studies. Lancet. 2009;373(9669):1083–96. doi:10.1016/S0140-6736(09)60318-4.

    Article  Google Scholar 

  4. Flegal KM, Kit BK, Orpana H, et al. Association of all-cause mortality with overweight and obesity using standard body mass index categories: a systematic review and meta-analysis. JAMA J Am Med Assoc. 2013;309(1):71–82. doi:10.1001/jama.2012.113905.

    Article  CAS  Google Scholar 

  5. Adams TD, Gress RE, Smith SC, et al. Long-term mortality after gastric bypass surgery. N Engl J Med. 2007;357(8):753–61. doi:10.1056/NEJMoa066603.

    Article  CAS  PubMed  Google Scholar 

  6. Buchwald H, Avidor Y, Braunwald E, et al. Bariatric surgery: a systematic review and meta-analysis. JAMA J Am Med Assoc. 2004;292(14):1724–37. doi:10.1001/jama.292.14.1724.

    Article  CAS  Google Scholar 

  7. Sjostrom L, Lindroos AK, Peltonen M, et al. Lifestyle, diabetes, and cardiovascular risk factors 10 years after bariatric surgery. N Engl J Med. 2004;351(26):2683–93. doi:10.1056/NEJMoa035622.

    Article  PubMed  Google Scholar 

  8. Sjostrom L, Narbro K, Sjostrom CD, et al. Effects of bariatric surgery on mortality in Swedish obese subjects. N Engl J Med. 2007;357(8):741–52. doi:10.1056/NEJMoa066254.

    Article  PubMed  Google Scholar 

  9. Buchwald H, Oien DM. Metabolic/bariatric surgery worldwide 2008. Obes Surg. 2009;19(12):1605–11. doi:10.1007/s11695-009-0014-5.

    Article  PubMed  Google Scholar 

  10. Buchwald H, Oien DM. Metabolic/bariatric surgery worldwide 2011. Obes Surg. 2013;23(4):427–36. doi:10.1007/s11695-012-0864-0.

    Article  PubMed  Google Scholar 

  11. Lomanto D, Lee WJ, Goel R, et al. Bariatric surgery in Asia in the last 5 years (2005–2009). Obes Surg. 2012;22(3):502–6. doi:10.1007/s11695-011-0547-2.

    Article  PubMed  Google Scholar 

  12. Rutledge R. The mini-gastric bypass: experience with the first 1,274 cases. Obes Surg. 2001;11(3):276–80. doi:10.1381/096089201321336584.

    Article  CAS  PubMed  Google Scholar 

  13. Fisher BL, Buchwald H, Clark W, et al. Mini-gastric bypass controversy. Obes Surg. 2001;11(6):773–7.

    CAS  PubMed  Google Scholar 

  14. Lee WJ, Yu PJ, Wang W, et al. Laparoscopic Roux-en-Y versus mini-gastric bypass for the treatment of morbid obesity: a prospective randomized controlled clinical trial. Ann Surg. 2005;242(1):20–8.

    Article  PubMed Central  PubMed  Google Scholar 

  15. Johnson WH, Fernanadez AZ, Farrell TM, et al. Surgical revision of loop (“mini”) gastric bypass procedure: multicenter review of complications and conversions to Roux-en-Y gastric bypass. Surg Obes Relat Dis Off J Am Soc Bariatric Surg. 2007;3(1):37–41. doi:10.1016/j.soard.2006.09.012.

    Article  Google Scholar 

  16. Carbajo M, Garcia-Caballero M, Toledano M, et al. One-anastomosis gastric bypass by laparoscopy: results of the first 209 patients. Obes Surg. 2005;15(3):398–404. doi:10.1381/0960892053576677.

    Article  PubMed  Google Scholar 

  17. Carbajo MA, Castro MJ, Kleinfinger S, et al. Effects of a balanced energy and high protein formula diet (Vegestart complet(R)) vs. low-calorie regular diet in morbid obese patients prior to bariatric surgery (laparoscopic single anastomosis gastric bypass): a prospective, double-blind randomized study. Nutr Hosp. 2010;25(6):939–48.

    CAS  PubMed  Google Scholar 

  18. Chakhtoura G, Zinzindohoue F, Ghanem Y, et al. Primary results of laparoscopic mini-gastric bypass in a French obesity-surgery specialized university hospital. Obes Surg. 2008;18(9):1130–3. doi:10.1007/s11695-008-9594-8.

    Article  PubMed  Google Scholar 

  19. Garcia-Caballero M, Valle M, Martinez-Moreno JM, et al. Resolution of diabetes mellitus and metabolic syndrome in normal weight 24–29 BMI patients with one anastomosis gastric bypass. Nutr Hosp. 2012;27(2):623–31. doi:10.1590/S0212-16112012000200041.

    CAS  PubMed  Google Scholar 

  20. Kim Z, Hur KY. Laparoscopic mini-gastric bypass for type 2 diabetes: the preliminary report. World J Surg. 2011;35(3):631–6. doi:10.1007/s00268-010-0909-2.

    Article  PubMed  Google Scholar 

  21. Noun R, Riachi E, Zeidan S, et al. Mini-gastric bypass by mini-laparotomy: a cost-effective alternative in the laparoscopic era. Obes Surg. 2007;17(11):1482–6.

    Article  PubMed  Google Scholar 

  22. Peraglie C. Laparoscopic mini-gastric bypass (LMGB) in the super-super obese: outcomes in 16 patients. Obes Surg. 2008;18(9):1126–9. doi:10.1007/s11695-008-9574-z.

    Article  PubMed  Google Scholar 

  23. Rutledge R, Walsh TR. Continued excellent results with the mini-gastric bypass: six-year study in 2,410 patients. Obes Surg. 2005;15(9):1304–8. doi:10.1381/096089205774512663.

    Article  PubMed  Google Scholar 

  24. Clarke MG, Wong K, Pearless L, et al. Laparoscopic silastic ring mini-gastric bypass: a single centre experience. Obes Surg. 2013;23(11):1852–7. doi:10.1007/s11695-013-1025-9.

    Article  CAS  PubMed  Google Scholar 

  25. Darabi S, Talebpour M, Zeinoddini A, et al. Laparoscopic gastric plication versus mini-gastric bypass surgery in the treatment of morbid obesity: a randomized clinical trial. Surg Obes Relat Dis Off J Am Soc Bariatric Surg. 2013;9(6):914–9. doi:10.1016/j.soard.2013.07.012.

    Article  Google Scholar 

  26. Kular KS, Manchanda N, Rutledge R. A 6-year experience with 1,054 mini-gastric bypasses—first study from Indian Subcontinent. Obes Surg. 2014. doi:10.1007/s11695-014-1220-3.

    Google Scholar 

  27. Lee WJ, Ser KH, Lee YC, et al. Laparoscopic Roux-en-Y vs. mini-gastric bypass for the treatment of morbid obesity: a 10-year experience. Obes Surg. 2012;22(12):1827–34.

    Article  PubMed  Google Scholar 

  28. Musella M, Susa A, Greco F, et al. The laparoscopic mini-gastric bypass: the Italian experience: outcomes from 974 consecutive cases in a multicenter review. Surg Endosc. 2014;28(1):156–63. doi:10.1007/s00464-013-3141-y.

    Article  CAS  PubMed  Google Scholar 

  29. Noun R, Skaff J, Riachi E, et al. One thousand consecutive mini-gastric bypass: short- and long-term outcome. Obes Surg. 2012;22(5):697–703. doi:10.1007/s11695-012-0618-z.

    Article  PubMed  Google Scholar 

  30. Mahawar KK, Carr WR, Balupuri S, et al. Controversy surrounding ‘mini’ gastric bypass. Obes Surg. 2014;24(2):324–33. doi:10.1007/s11695-013-1090-0.

    Article  PubMed  Google Scholar 

  31. Mahawar KK, Jennings N, Brown J, et al. “Mini” gastric bypass: systematic review of a controversial procedure. Obes Surg. 2013;23(11):1890–8. doi:10.1007/s11695-013-1026-8.

    Article  PubMed  Google Scholar 

  32. Mason EE, Ito C. Gastric bypass in obesity. Surg Clin N Am. 1967;47(6):1345–51.

    CAS  PubMed  Google Scholar 

  33. Ser KH, Lee WJ, Lee YC, et al. Experience in laparoscopic sleeve gastrectomy for morbidly obese Taiwanese: staple-line reinforcement is important for preventing leakage. Surg Endosc. 2010;24(9):2253–9. doi:10.1007/s00464-010-0945-x.

    Article  PubMed  Google Scholar 

  34. Lee WJ, Huang MT, Wang W, et al. Effects of obesity surgery on the metabolic syndrome. Arch Surg. 2004;139(10):1088–92. doi:10.1001/archsurg.139.10.1088.

    Article  PubMed  Google Scholar 

  35. Lee WJ, Wang W, Lee YC, et al. Effect of laparoscopic mini-gastric bypass for type 2 diabetes mellitus: comparison of BMI>35 and <35 kg/m2. J Gastrointest Surg Off J Soc Surg Aliment Tract. 2008;12(5):945–52. doi:10.1007/s11605-007-0319-4.

    Article  Google Scholar 

  36. Lee WJ, Wang W, Lee YC, et al. Laparoscopic mini-gastric bypass: experience with tailored bypass limb according to body weight. Obes Surg. 2008;18(3):294–9. doi:10.1007/s11695-007-9367-9.

    Article  PubMed  Google Scholar 

  37. Sanchez-Pernaute A, Herrera MA, Perez-Aguirre ME, et al. Single anastomosis duodeno-ileal bypass with sleeve gastrectomy (SADI-S). One to three-year follow-up. Obes Surg. 2010;20(12):1720–6. doi:10.1007/s11695-010-0247-3.

    Article  PubMed  Google Scholar 

  38. Sanchez-Pernaute A, Rubio Herrera MA, Perez-Aguirre E, et al. Proximal duodenal-ileal end-to-side bypass with sleeve gastrectomy: proposed technique. Obes Surg. 2007;17(12):1614–8. doi:10.1007/s11695-007-9287-8.

    Article  PubMed  Google Scholar 

  39. El-Kadre L, Tinoco AC, Tinoco RC, et al. Overcoming the learning curve of laparoscopic Roux-en-Y gastric bypass: a 12-year experience. Surg Obes Relat Dis Off J Am Soc Bariatric Surg. 2013;9(6):867–72. doi:10.1016/j.soard.2013.01.020.

    Article  Google Scholar 

  40. Schauer P, Ikramuddin S, Hamad G, et al. The learning curve for laparoscopic Roux-en-Y gastric bypass is 100 cases. Surg Endosc. 2003;17(2):212–5. doi:10.1007/s00464-002-8857-z.

    Article  CAS  PubMed  Google Scholar 

  41. Wang W, Wei PL, Lee YC, et al. Short-term results of laparoscopic mini-gastric bypass. Obes Surg. 2005;15(5):648–54. doi:10.1381/0960892053923752.

    Article  PubMed  Google Scholar 

  42. Hwang RF, Swartz DE, Felix EL. Causes of small bowel obstruction after laparoscopic gastric bypass. Surg Endosc. 2004;18(11):1631–5. doi:10.1007/s00464-004-8804-2.

    Article  CAS  PubMed  Google Scholar 

  43. Lopez-Tomassetti Fernandez EM, Arteaga Gonzalez I, Diaz-Luis H, et al. Obstruction of the bypassed stomach treated with percutaneous drainage: an alternative treatment for selected cases. Obes Surg. 2008;18(2):233–6. doi:10.1007/s11695-007-9246-4.

    Article  CAS  PubMed  Google Scholar 

  44. Higa KD, Boone KB, Ho T, et al. Laparoscopic Roux-en-Y gastric bypass for morbid obesity: technique and preliminary results of our first 400 patients. Arch Surg. 2000;135(9):1029–33. discussion 33–4.

    Article  CAS  PubMed  Google Scholar 

  45. Hsieh T, Zurita L, Grover H, et al. 10-year outcomes of the vertical transected gastric bypass for obesity: a systematic review. Obes Surg. 2014;24(3):456–61. doi:10.1007/s11695-013-1161-2.

    Article  PubMed  Google Scholar 

  46. Dixon JB, Chuang LM, Chong K, et al. Predicting the glycemic response to gastric bypass surgery in patients with type 2 diabetes. Diabetes Care. 2013;36(1):20–6. doi:10.2337/dc12-0779.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  47. Ochner CN, Gibson C, Shanik M, et al. Changes in neurohormonal gut peptides following bariatric surgery. Int J Obes. 2011;35(2):153–66. doi:10.1038/ijo.2010.132.

    Article  CAS  Google Scholar 

  48. Karamanakos SN, Vagenas K, Kalfarentzos F, et al. Weight loss, appetite suppression, and changes in fasting and postprandial ghrelin and peptide-YY levels after Roux-en-Y gastric bypass and sleeve gastrectomy: a prospective, double blind study. Ann Surg. 2008;247(3):401–7. doi:10.1097/SLA.0b013e318156f012.

    Article  PubMed  Google Scholar 

  49. Korner J, Inabnet W, Febres G, et al. Prospective study of gut hormone and metabolic changes after adjustable gastric banding and Roux-en-Y gastric bypass. Int J Obes. 2009;33(7):786–95. doi:10.1038/ijo.2009.79.

    Article  CAS  Google Scholar 

  50. Lee WJ, Chen CY, Chong K, et al. Changes in postprandial gut hormones after metabolic surgery: a comparison of gastric bypass and sleeve gastrectomy. Surg Obes Relat Dis Off J Am Soc Bariatric Surg. 2011;7(6):683–90. doi:10.1016/j.soard.2011.07.009.

    Article  Google Scholar 

  51. Lee WJ, Lee YC, Ser KH, et al. Revisional surgery for laparoscopic minigastric bypass. Surg Obes Relat Dis Off J Am Soc Bariatric Surg. 2011;7(4):486–91. doi:10.1016/j.soard.2010.10.012.

    Article  Google Scholar 

  52. Paroz A, Calmes JM, Giusti V, et al. Internal hernia after laparoscopic Roux-en-Y gastric bypass for morbid obesity: a continuous challenge in bariatric surgery. Obes Surg. 2006;16(11):1482–7. doi:10.1381/096089206778870102.

    Article  CAS  PubMed  Google Scholar 

  53. Hansson LE, Nyren O, Hsing AW, et al. The risk of stomach cancer in patients with gastric or duodenal ulcer disease. N Engl J Med. 1996;335(4):242–9. doi:10.1056/NEJM199607253350404.

    Article  CAS  PubMed  Google Scholar 

  54. Wu CC, Lee WJ, Ser KH, et al. Gastric cancer after mini-gastric bypass surgery: a case report and literature review. Asian J Endoscopic Surg. 2013;6(4):303–6. doi:10.1111/ases.12052.

    Article  Google Scholar 

  55. Rieu PN, Jansen JB, Biemond I, et al. Short-term results of gastrectomy with Roux-en-Y or Billroth II anastomosis for peptic ulcer. Prospect Comp Study Hepato-gastroenterol. 1992;39(1):22–6.

    CAS  Google Scholar 

  56. Csendes A, Burgos AM, Smok G, et al. Latest results (12–21 years) of a prospective randomized study comparing Billroth II and Roux-en-Y anastomosis after a partial gastrectomy plus vagotomy in patients with duodenal ulcers. Ann Surg. 2009;249(2):189–94. doi:10.1097/SLA.0b013e3181921aa1.

    Article  PubMed  Google Scholar 

  57. Lee WJ, Lee KT, Kasama K, et al. Laparoscopic single-anastomosis duodenal-jejunal bypass with sleeve gastrectomy (SADJB-SG): short-term result and comparison with gastric bypass. Obes Surg. 2014;24(1):109–13. doi:10.1007/s11695-013-1067-z.

    Article  PubMed  Google Scholar 

  58. Lee WJ, Wang W, Chen TC, et al. Totally laparoscopic radical BII gastrectomy for the treatment of gastric cancer: a comparison with open surgery. Surg Laparosc Endosc Percutaneous Tech. 2008;18(4):369–74. doi:10.1097/SLE.0b013e31816fdd44.

    Article  CAS  Google Scholar 

  59. Huscher CG, Mingoli A, Sgarzini G, et al. Laparoscopic versus open subtotal gastrectomy for distal gastric cancer: five-year results of a randomized prospective trial. Ann Surg. 2005;241(2):232–7.

    Article  PubMed Central  PubMed  Google Scholar 

  60. Kim HH, Hyung WJ, Cho GS, et al. Morbidity and mortality of laparoscopic gastrectomy versus open gastrectomy for gastric cancer: an interim report—a phase III multicenter, prospective, randomized trial (KLASS Trial). Ann Surg. 2010;251(3):417–20. doi:10.1097/SLA.0b013e3181cc8f6b.

    Article  PubMed  Google Scholar 

  61. Kitano S, Shiraishi N, Uyama I, et al. A multicenter study on oncologic outcome of laparoscopic gastrectomy for early cancer in Japan. Ann Surg. 2007;245(1):68–72. doi:10.1097/01.sla.0000225364.03133.f8.

    Article  PubMed Central  PubMed  Google Scholar 

  62. Lee WJ, Chen TC, Lai IR, et al. Randomized clinical trial of Ligasure versus conventional surgery for extended gastric cancer resection. Br J Surg. 2003;90(12):1493–6. doi:10.1002/bjs.4362.

    Article  PubMed  Google Scholar 

  63. Kuo WH, Lee WJ, Chen CN, et al. Laparoscopic subtotal gastrectomy with lymphadenectomy in a patient with early gastric cancer. J Formos Med Assoc Taiwan yi zhi. 1998;97(2):127–30.

    CAS  Google Scholar 

  64. Lee WJ, Huang MT, Lai IR, et al. Laparoscopic vertical banded gastric partition. Formos J Surg. 1999;v.32(n.4):165–71.

    Google Scholar 

  65. Lee WJ, Huang MT, Lai IR. Laparoscopic Roux-en-Y gastric bypass for morbid obesity. Formos J Surg. 2003;36:104–11.

    Google Scholar 

  66. Braghetto I, Korn O, Csendes A, et al. Laparoscopic treatment of obese patients with gastroesophageal reflux disease and Barrett's esophagus: a prospective study. Obes Surg. 2012;22(5):764–72. doi:10.1007/s11695-011-0531-x.

    Article  PubMed  Google Scholar 

  67. Varela JE, Hinojosa MW, Nguyen NT. Laparoscopic fundoplication compared with laparoscopic gastric bypass in morbidly obese patients with gastroesophageal reflux disease. Surg Obes Relat Dis Off J Am Soc Bariatric Surg. 2009;5(2):139–43. doi:10.1016/j.soard.2008.08.021.

    Article  Google Scholar 

  68. Jimenez A, Casamitjana R, Flores L, et al. Long-term effects of sleeve gastrectomy and Roux-en-Y gastric bypass surgery on type 2 diabetes mellitus in morbidly obese subjects. Ann Surg. 2012;256(6):1023–9. doi:10.1097/SLA.0b013e318262ee6b.

    Article  PubMed  Google Scholar 

  69. Yang X, Yang G, Wang W, et al. A meta-analysis: to compare the clinical results between gastric bypass and sleeve gastrectomy for the obese patients. Obes Surg. 2013;23(7):1001–10. doi:10.1007/s11695-013-0938-7.

    Article  PubMed  Google Scholar 

  70. Lee WJ, Chong K, Ser KH, et al. Gastric bypass vs sleeve gastrectomy for type 2 diabetes mellitus: a randomized controlled trial. Arch Surg. 2011;146(2):143–8. doi:10.1001/archsurg.2010.326.

    Article  PubMed  Google Scholar 

  71. Milone M, Di Minno MN, Leongito M, et al. Bariatric surgery and diabetes remission: sleeve gastrectomy or mini-gastric bypass? World J Gastroenterol WJG. 2013;19(39):6590–7. doi:10.3748/wjg.v19.i39.6590.

    Article  Google Scholar 

  72. Dixon JB, Hur KY, Lee WJ, et al. Gastric bypass in type 2 diabetes with BMI < 30: weight and weight loss have a major influence on outcomes. Diabet Med J Br Diabet Assoc. 2013;30(4):e127–34. doi:10.1111/dme.12107.

    Article  CAS  Google Scholar 

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Dr. Wei-Jei Lee and Dr. Yu-Hung Lin have no conflict of interest.

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Lee, WJ., Lin, YH. Single-Anastomosis Gastric Bypass (SAGB): Appraisal of Clinical Evidence. OBES SURG 24, 1749–1756 (2014). https://doi.org/10.1007/s11695-014-1369-9

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