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Whole-body MRI in patients with lymphoma: collateral findings

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Abstract

Purpose

To assess the incidence of collateral findings detected on whole-body magnetic resonance (WB-MRI) scans performed on patients with lymphoma.

Materials and methods

114 patients (65 male; median age 45.2 years, range 15–86) with histologically confirmed lymphoma (47 Hodgkin, 67 Non-Hodgkin) underwent WB-MRI. The collateral findings were classified into three classes, according to their clinical significance, as follows: not or low significant (class 1), moderately or potentially significant (class 2), and significant (class 3). A Chi-square (χ 2) test was performed to assess the statistical significance of differences in the incidence of collateral findings based on age (≤50 and >50 years old), gender and histology (Hodgkin and Non-Hodgkin Lymphoma).

Results

Ninety-one of 114 patients (79.8 %) had one or more incidental findings on WB-MRI. Collateral findings were more frequent in class 1 (43 %); abnormalities found in 35 patients (30.7 %) were considered potentially significant, whereas seven patients (6.1 %) demonstrated significant collateral findings requiring immediate treatment or further diagnostic evaluation. Collateral findings were more frequent in subjects over 50 years old compared to those of 50 years old or younger; differences were statistical significant (χ 2 = 8.42, p < 0.05). There were not statistically significant differences related to gender (χ 2 = 0.17, p > 0.05) and histology (χ 2 = 0.24, p > 0.05).

Conclusion

WB-MRI is an attractive procedure that allows to detect incidental abnormalities of organs not involved by disease offering the opportunity to obtain an early diagnosis of asymptomatic life-threatening diseases.

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Authors and Affiliations

  1. Department of Radiology, DIBIMED, University of Palermo, Via del Vespro 127, 90127, Palermo, Italy

    Massimo Galia, Domenico Albano, Donatella Narese, Emanuele Grassedonio, Ludovico La Grutta, Roberto Lagalla & Massimo Midiri

  2. Department of Hematology I, Azienda Ospedali Riuniti Villa Sofia-Cervello, Viale Strasburgo 233, 90146, Palermo, Italy

    Caterina Patti & Antonino Mulè

  3. Dipartimento di Scienze Biomediche Avanzate, Università degli studi Federico II, Via Pansini 5, 80131, Naples, Italy

    Vito Chianca

  4. Dipartimento di Diagnostica per Immagini, AORN A. Cardarelli, Via Antonio Cardarelli 9, 80131, Naples, Italy

    Francesco Di Pietto

Authors
  1. Massimo Galia
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  2. Domenico Albano
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  4. Caterina Patti
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  8. Emanuele Grassedonio
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  9. Ludovico La Grutta
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Correspondence to Domenico Albano.

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The authors declare that they have no conflict of interest.

Ethical standards

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. For this type of study, formal consent is not required.

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Informed consent was obtained from all individual participants included in the study.

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Galia, M., Albano, D., Narese, D. et al. Whole-body MRI in patients with lymphoma: collateral findings. Radiol med 121, 793–800 (2016). https://doi.org/10.1007/s11547-016-0658-x

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  • DOI: https://doi.org/10.1007/s11547-016-0658-x

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