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Magnetic nanoparticles for a new drug delivery system to control quercetin releasing for cancer chemotherapy

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Abstract

Quercetin belongs to the chemical class of flavonoids and can be found in many common foods, such as apples, nuts, berries, etc. It has been demonstrated that quercetin has a wide array of biological effects that are considered beneficial to health treatment, mainly as anticancer. However, therapeutic applications of quercetin have been restricted to oral administration due to its sparing solubility in water and instability in physiological medium. A drug delivery methodology was proposed in this work to study a new quercetin release system in the form of magnetite–quercetin–copolymer (MQC). These materials were characterized through XRD, TEM, IR, and Thermal analysis. In addition, the magnetization curves and quercetin releasing experiments were performed. It was observed a nanoparticle average diameter of 11.5 and 32.5 nm at Fe3O4 and MQC, respectively. The presence of magnetic nanoparticles in this system offers the promise of targeting specific organs within the body. These results indicate the great potential for future applications of the MQC to be used as a new quercetin release system.

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Acknowledgments

The authors thank Dr. Zhuo Yang for the preparation and characterization of copolymer E137S18E137. The study was supported by CAPES, Funcap and CNPq (Brazilian agencies). Financiamiento Basal para Centros Cientificos y Tecnologicos de Excelencia CEDENNA), Millennium Science Nucleus Basic and Applied Magnetism (P06-022F) and Fondecyt 1080164 and 3100117.

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Authors and Affiliations

  1. Grupo de Química de Materiais Avançados (GQMAT), Departamento de Química Analítica e Físico-Química, Universidade Federal do Ceará – UFC, Campus do Pici, CP 12100, Fortaleza, CE, 60451-970, Brazil

    A. C. H. Barreto, V. R. Santiago & P. B. A. Fechine

  2. Laboratório de Produtos e Tecnologia em Processos—LPT, Departamento de Química Orgânica e Inorgânica, Universidade Federal do Ceará, Fortaleza, CE, Brazil

    A. C. H. Barreto, V. R. Santiago & S. E. Mazzetto

  3. Departamento de Física, Universidad de Santiago de Chile, USACH, Av. Ecuador, 3493, Santiago, Chile

    J. C. Denardin & R. Lavín

  4. Facultad de Ingeniería, Universidad Diego Portales, Ejército 441, Santiago, Chile

    R. Lavín

  5. Dipartimento di Ingegneria dell’Innovazione, Università del Salento, 73100, Via Arnesano, LE, Italy

    Giuseppe Mele

  6. Departamento de Química Orgânica e Inorgânica, Universidade Federal do Ceará, CX 6.021, Fortaleza, CE, 60455-760, Brazil

    M. E. N. P. Ribeiro & N. M. P. S. Ricardo

  7. Parque de Desenvolvimento Tecnológico (PADETEC), Campus do Pici, Fortaleza, CE, 60455-970, Brazil

    Icaro G. P. Vieira

  8. Departamento de Farmácia, Universidade Federal do Ceará, Fortaleza, CE, Brazil

    Tamara Gonçalves

Authors
  1. A. C. H. Barreto
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  2. V. R. Santiago
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  3. S. E. Mazzetto
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  4. J. C. Denardin
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  5. R. Lavín
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  6. Giuseppe Mele
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  7. M. E. N. P. Ribeiro
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  8. Icaro G. P. Vieira
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  9. Tamara Gonçalves
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  10. N. M. P. S. Ricardo
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  11. P. B. A. Fechine
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Corresponding author

Correspondence to P. B. A. Fechine.

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Barreto, A.C.H., Santiago, V.R., Mazzetto, S.E. et al. Magnetic nanoparticles for a new drug delivery system to control quercetin releasing for cancer chemotherapy. J Nanopart Res 13, 6545–6553 (2011). https://doi.org/10.1007/s11051-011-0559-9

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  • DOI: https://doi.org/10.1007/s11051-011-0559-9

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