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A dual-stimuli-responsive delivery system for poorly water-soluble drug based on iron oxide nanoparticles

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Abstract

This study aimed to prepared a dual-stimuli-responsive delivery system based on iron oxide nanoparticles (IONPs) and Pluronic F127—Folic acid conjugation (F127-FA) for poorly water-soluble drugs. Oleic acid-coated IONPs were prepared and modified with F127-FA using ultrasonic treatment to form IONPs/F127-FA meanwhile Quercetin (QCT)—a poorly water-soluble drug was encapsulated into the nano-system. The results illustrated the successful preparation of IONPs/F127-FA and its saturation magnetization value was found to be 25.6 emu/g. Moreover, QCT was effectively entrapped into the synthesized IONPs/F127-FA and showed 23.45 ± 7.23% loading capacity and 89.87 ± 2.05% entrapment efficiency. Additionally, the MTT assay revealed that loaded QCT in IONPs/F127-FA showed high inhibition against the human breast cancer cells compared to the free one, which was attributed to the ability to bind to folate receptor α of IONPs/F127-FA. These results suggested that the IONPs/F127-FA system would be a promising dual-stimuli-responsive drug delivery system in cancer treatment.

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Data availability

The data that support the findings of this study are available upon reasonable request.

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Funding

This research is funded by the Vietnam Academy of Science and Technology (VAST) under grant number NVCC19.04/22–23.

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Author notes

    Authors and Affiliations

    1. Institute of Chemical Technology, Vietnam Academy of Science and Technology, 1A TL29 District 12, Ho Chi Minh City, 700000, Vietnam

      Tien-Dung Nguyen-Dinh, Ngoc Hoi Nguyen & Dai Hai Nguyen

    2. Institute of Applied Materials Science, Vietnam Academy of Science and Technology, 1B TL29 District 12, Ho Chi Minh City, 700000, Vietnam

      Tien-Dung Nguyen-Dinh, Nhu-Thuan Nguyen-Phuoc, Ngoc Thuy Trang Le & Dai Hai Nguyen

    3. Graduate University of Science and Technology, Vietnam Academy of Science and Technology, Hanoi, 100000, Vietnam

      Tien-Dung Nguyen-Dinh & Dai Hai Nguyen

    4. Faculty of Chemistry, University of Science, Vietnam National University, Ho Chi Minh City, 700000, Vietnam

      Nhu-Thuan Nguyen-Phuoc

    Author notes

    1. Tien-Dung Nguyen-Dinh and Nhu-Thuan Nguyen-Phuoc have contributed equally to this work.

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      1. Tien-Dung Nguyen-Dinh
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      Contributions

      T-DN-D contributed to methodology, software, conceiving and designing the analysis, and data curation. N-TN-P contributed to methodology, conceiving and designing the analysis, data curation, and software. NTTL contributed to visualization, validation, collection the data, and performing the analysis. NHN contributed to conceiving and designing the analysis, contributing the data or analysis tools, and writing and original draft preparation. DHN contributed to investigation, conceptualization, supervision, and writing, reviewing, and editing of the manuscript.

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      Correspondence to Dai Hai Nguyen.

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      Nguyen-Dinh, TD., Nguyen-Phuoc, NT., Le, N.T.T. et al. A dual-stimuli-responsive delivery system for poorly water-soluble drug based on iron oxide nanoparticles. Journal of Materials Research 38, 4057–4067 (2023). https://doi.org/10.1557/s43578-023-01120-8

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